喷雾型化妆品局部耐受性评估与安全监管讨论

Review on Local Tolerance Assessment and Safety Supervision of Sprayable Cosmetic Products

皮肤是大多数化妆品的主要暴露部位,然而随着喷雾型化妆品日益流行,化妆品在使用过程中产生的消费者吸入暴露以及随之而来的健康风险不容忽视,国内外监管机构对此发布了一些技术要求。分析比较了人体皮肤与呼吸道在结构、功能以及刺激/过敏发生机制上的差异,并基于当前呼吸道局部耐受性评价方法发展现状,对喷雾型化妆品及新原料提出了安全监管建议。

For most of cosmetic products,skin is the major exposure site of human body.Since the sprayable cosmetics become popular,consumer exposure via inhalation is then probable and needs to be taken into consideration in the overall health risk assessment in view of the intended use of the products.The authorities in China or other parts of the world have issued several regulatory requirements in response to this concern.The differences in histology,physiological function,and mechanisms of action of irritation/sensitization between human skin and respiratory tract were reviewed,as well as the state of the art in local tolerance testing for inhalation exposure.In the end,a proposal was presented for safety supervision of sprayable cosmetic products and especially,the new cosmetic ingredients still under assessment.