摘要
动脉粥样硬化(atherosclerosis, As)的发展过程与炎症反应、脂质代谢紊乱以及环境等因素密切相关。表观遗传的研究主要涉及DNA甲基化、非编码RNA调控、组蛋白修饰和染色质重塑等调节机制。越来越多的研究揭示表观遗传参与了As的发生发展。表观遗传的异常变化在介导泡沫细胞产生、内皮功能障碍、血管平滑肌细胞(vascular smooth muscle cell,VSMC)表型转换等方面发挥着关键作用。文章对表观遗传在As中的调控机制和治疗作用进行阐述,并总结其最新研究进展,旨在从非遗传因素角度为临床As的早期诊断和个性化治疗提供参考。
The development of atherosclerosis(As)is closely related to inflammatory response,lipid metabolism disorders and environmental factors.Epigenetic studies are concerned with regulatory mechanisms such as DNA methylation,non-coding RNA regulation,histone modifications and chromatin remodeling.An increasing number of studies have revealed the involvement of epigenetics in the development of As.Aberrant epigenetic changes play a key role in mediating foam cell production,endothelial dysfunction,and vascular smooth muscle cell(VSMC)phenotype transformation.In this paper,we describe the regulatory mechanisms and therapeutic roles of epigenetics in As,and summarize the latest research progress,aiming to provide a reference for early diagnosis and personalized treatments of clinical As from the perspective of non-genetic factors.
作者
童晓岚
宋佳欣
姜继宗
TONG Xiaoan;SONG Jiaxin;JIANG Jizong(Shanghai Engineering Research Center of Organ Repair,School of Medicine,Shanghai University,Shanghai 200444,China;School of Life Sciences,Shanghai University,Shanghai 200444,China)
出处
《自然杂志》
CAS
2024年第1期73-82,共10页
Chinese Journal of Nature
基金
上海市2022年度“科技创新行动计划”自然科学基金面上项目(22ZR1423100)。
