独立验证软件Arc QA与Veri QA在调强放疗计划验证中的剂量学比较

Dosimetric Comparison of Independent Verification Software of Arc QA and Veri QA in IMRT Plans

目的评估并比较基于蒙特卡罗算法的Arc QA和Veri QA 2款独立剂量验证软件在调强计划验证中的剂量学差异。方法收集87例行调强放疗患者的放疗计划,包括头颈部17例、胸部46例、腹部24例,所有放疗计划均通过了临床剂量验证。分别使用Arc QA和Veri QA对调强计划进行独立剂量计算,采用γ通过率(3%/3 mm)分析二者与治疗计划系统(Treatment Planning System,TPS)间的剂量分布,并对比二者的靶区剂量-体积直方图参数(最小剂量、最大剂量、平均剂量和D95%)剂量验算差异和γ通过率。结果Arc QA和Veri QA与TPS间关于靶区的剂量差异均在±2.5%以内,2款软件在头颈、胸及腹部中的平均γ通过率分别为98.90%±1.99%和99.21%±0.85%、95.74%±3.16%和99.37%±0.77%以及97.10%±2.41%和99.84%±0.17%,二者在胸腹部差异均有统计学意义(t=-5.972,P<0.05;t=-5.133,P<0.05)。结论Arc QA和Veri QA与TPS均有良好的剂量学一致性,能满足临床验证需要,可作为调强计划的独立验证工具。

Objective To evaluate and compare the dosimetric differences of two independent dose verification software in IMRT plans,which are Arc QA and Veri QA based on Monte Carlo algorithm.Methods A total of 87 patients were enrolled in IMRT plans,including 17 for the head and neck,46 for the chest,and 24 for the abdomen.All radiotherapy plans had passed clinical dose verification.Arc QA and Veri QA were respectively adopted to conduct independent dose calculation for IMRT plans,usedγpass rate(3%/3 mm)to analyze the dose distribution between the two verification software and treatment planning system(TPS),and compared the dose differences in PTV dose-volume histogram parameters(including minimum dose,maximum dose,average dose,and D95%)andγpass rate between Arc QA and Veri QA.Results The dose difference between Arc QA,Veri QA and TPS in PTV was within±2.5%.Theγpass rates of Arc QA and Veri QA on head and neck,chest and abdomen were 98.90%±1.99%and 99.21%±0.85%,95.74%±3.16%and 99.37%±0.77%,as well as 97.10%±2.41%and 99.84%±0.17%,respectively.There was a statistically significant difference between the two software in chest and abdomen(t=-5.972,P<0.05;t=-5.133,P<0.05).Conclusion Arc QA and Veri QA have good dosimetric consistency with TPS,which can meet clinical validation needs and serve as independent validation tools for intensity modulation plans.