探究化瘀明目饮对糖尿病性白内障患者疗效及黄斑视网膜厚度变化情况的作用机制

ffExploration on the effect of Huayu Mingmu Yin on diabetic cataract patients and its mechanism on the macular retinal thickness changes

目的探讨糖尿病性白内障(DC)患者应用化瘀明目饮对临床疗效、黄斑视网膜厚度以及不良反应的影响。方法选取2021年7月-2022年6月我院收治的180例糖尿病白内障患者,采用随机数表法将其分为观察组和对照组,各90例。对照组给予眼部注射康柏西普3个月,观察组采用化瘀明目饮联合康柏西普治疗3个月,比较2组临床疗效和不良反应发生率,对比2组治疗前后黄斑视网膜厚度、黄斑总容积、眼压、视力、实验室指标变化。结果治疗后观察组临床疗效明显高于对照组(P<0.05);治疗后观察组黄斑视中心凹处的视网膜厚度、周边部视网膜厚度和黄斑总容积明显低于对照组(P<0.05);治疗后2组眼压和视力均上升,且观察组更高(P<0.05);治疗后2组血管内皮生长因子(VEGF)、白细胞介素-6(IL-6)均下降,且观察组2项指标水平更低(P<0.05);治疗后观察组不良反应发生率更低(P<0.05)。结论化瘀明目饮可改善DC患者黄斑视网膜厚度、血管生成,提高视力并减轻炎症,从而提升临床疗效,对后续治疗DM患者提供重要参考意义。

Objective To explore the effects of Huayu Mingmu Yin on the clinical efficacy,macular retinal thickness and adverse reactions in patients with diabetic cataract(DC).Methods A total of 180 diabetic cataract patients admitted to our hospital from July 2021 to June 2022 were selected as the research subjects,and were divided into an observation group and a control group by a random number table method,with 90 cases in each group.The control group was given eye injections of Conbercept for 3 months,while the observation group was treated with Huayu Mingmu Yin combined with Conbercept for 3 months as well.The clinical efficacy and incidence of adverse reactions were compared between the two groups,and the changes of macular retinal thickness,total macular volume,intraocular pressure,visual acuity and laboratory indexes were compared between the two groups before and after treatment.Results After treatment,the clinical efficacy of the observation group was significantly higher than that of the control group(P<0.05).After treatment,the retinal thickness in the fovea,the peripheral retinal thickness and the total volume of macula were significantly lower in the observation group than those in the control group(P<0.05).After treatment,the intraocular pressure and visual acuity were increased in both groups,and the observation group was higher(P<0.05).After treatment,the levels of vascular endothelial growth factor(VEGF)and interleukin-6(IL-6)were decreased in both groups,and the levels of the two indexes were much lower in the observation group(P<0.05).The incidence of adverse reactions was much lower in the observation group after treatment(P<0.05).Conclusion Huayu Mingmu Yin can improve the macular retinal thickness and angiogenesis,improve vision and alleviate inflammation in DC patients,thereby enhancing the clinical efficacy and providing an important reference for the subsequent treatment of DM patients.