重构本草——黄药子

Reconstruction of Chinese materia medica-air potato

通过古籍文献调研、中医药现代研究成果的梳理,结合中医临床及中药学等学科领域内知名专家学者认识及应用经验,归纳了黄药子功效主要为:化痰散结消瘿,清热解毒,凉血止血。标靶为甲状腺肿物,高甲状腺激素和低促甲状腺激素。现代药理研究发现黄药子及其有效成分具有补碘、调节甲状腺相关激素水平、抗肿瘤、抗炎等作用。具有肝肾毒性,黄独素B是主要的肝毒性成分。临床使用剂量为6~15 g,首次使用不超过15 g,使用时需配伍“保肝”中药,并在服药期间定期复查肝功能以及时减量或停药。总之,需根据不同疾病,或同一疾病的不同阶段进行辨证使用,并积极探索黄药子用量与标靶的量效关系构建。

Through the investigation of ancient literature and the sorting of modern research achievements in traditional Chinese medicine,combined with the understanding and application experience of well-known experts and scholars in the clinical and pharmaceutical fields of traditional Chinese medicine,it is concluded that air potato is mainly characterized by the follows:Its main effects include dissipating phlegm,resolving masses,eliminating goiters,clearing heat and detoxifying,cooling blood and stopping bleeding.Its biochemical indicator targets are thyroid neoplasms,high thyroid hormone and low thyroid-stimulating hormone.Modern pharmacological studies have found that its active ingredients have the functions of supplementing iodine,regulating thyroid related hormone levels,antitumor,anti-inflammation,etc.It has hepatotoxicity and nephrotoxicity,and the Diosbulbin B is the main hepatotoxicity component.Its clinical dosage range is 6-15 g,and should not exceed 15 g for the first time.When using it,it should be combined with"liver protecting"traditional Chinese medicine,and regularly check the liver function during the medication period,and reduce the dosage or stop it in a timely manner.In short,it is necessary to differentiate and use air potato according to different diseases or different stages of the same disease,and the dose-effect relationship between its dosage and biochemical indicator targets should be actively explored and reconstructed.