高血压、血糖及血脂代谢异常与痛风发作部位和发作次数的关系分析

Correlation analysis between hypertension,abnormal blood glucose and lipid metabolism and the site and frequency of gout attack

目的探讨高血压、血糖及脂代谢异常与痛风发作部位和发作次数之间的关系。方法收集84例痛风患者的临床资料,记录患者的性别、年龄、身高、体质量、BMI、合并疾病、发作部位、发作次数等,比较不同发作部位临床指标间的差异,以及合并糖尿病、高血压、高脂血症者在不同时间点间发作次数的差异,采用Spearman秩相关分析年龄、BMI与发作次数间的关系。结果84例痛风患者中,男82例、女2例。年龄(37.95±10.16)岁,身高170(165,175)cm,体质量76(70,83)kg,BMI 26.5(24.6,29.3)kg/m^(2);合并糖尿病7例(8%)、高血压18例(21%)、高脂血症16例(19%)。患者发病部位以下肢为主,其中跖趾关节(38.10%)与踝关节(35.71%)最为多见,合并高血压、血糖及脂代谢异常与痛风发作部位无关(P均>0.05)。合并高血压的痛风患者在1个月、6个月、1年内的发作次数均多于未合并高血压的痛风患者(P均<0.05),且合并高血压的痛风患者发作次数随时间增加而增多(任意两个相邻时间点间比较P均<0.05/6)。痛风患者的BMI与总体1年内累计的发作次数呈正相关(r_(s)=0.28,P<0.05)。结论合并高血压的痛风患者发作次数多于无合并高血压的痛风患者,且发作次数随时间增加而增多,应积极控制痛风患者的血压及BMI,进而减少其发作次数。

Objective To analyze the correlation between hypertension,abnormal blood glucose and lipid metabolism and the site and frequency of gout attack.Methods Clinical data of 84 primary gout patients were collected.Gender,age,height,body weight,body mass index(BMI),complicated diseases,site and frequency of gout attack were recorded.The differences of clinical parameters at different sites of gout attack were compared.The differences of frequency of gout attack in patients complicated with diabetes mellitus,hypertension and hyperlipidemia at different time points were also compared.The relationship between age and BMI,and frequency of gout attack was assessed by Spearman’s rank correlation analysis.Results Among 84 patients with primary gout,82 patients were male and 2 female,aged(37.95±10.16)years on average,with a mean height of 170(165,175)cm,mean weight of 76(70,83)kg,mean BMI of 26.5(24.6,29.3)kg/m^(2).Among them,7 patients(8%)were complicated with diabetes mellitus,18 cases(21%)of hypertension and 16 cases(19%)of hyperlipidemia.the most common site of gout attack was the lower limb,especially the metatarsophalangeal joint(38.10%)and knee joint(35.71%).The frequency of gout attack within 1,6 and 12 months in gout patients complicated with hypertension was higher compared with that in those without hypertension(all P<0.05).The frequency of gout attack in gout patients complicated with hypertension was increased over time(all P<0.05/6 between any two consecutive time points).BMI of gout patients was positively correlated with 1-year cumulative frequency of gout attack(r_(s)=0.28,P<0.05).Conclusions The frequency of gout attack in patients complicated with hypertension is higher compared with that of their counterparts without hypertension.The frequency of gout attack is increased over time.Extensive attention should be diverted to blood pressure and BMI in gout patients,thereby reducing the frequency of gout attack.