强脉冲光联合甘醇酸治疗痤疮后红斑的疗效分析

Analysis of the therapeutic effect of intense pulse light combined with glycyrrhetinic acid in the treatment of erythema postacne

目的探讨观察强脉冲光联合甘醇酸治疗痤疮后红斑的临床疗效及安全性。方法回顾性分析2019年8月至2023年5月于陆军军医大学第一附属医院皮肤科行强脉冲光、强脉冲光联合30%甘醇酸治疗痤疮后红斑患者共141例,其中强脉冲光治疗组77例,强脉冲光联合30%甘醇酸治疗组64例。间隔4周治疗1次,总治疗3次。治疗3次后比较两组治疗后的临床疗效、临床医生红斑评估量表(CEAS)评分、满意度评分及不良反应。结果强脉冲光联合30%甘醇酸治疗组临床总有效率为60.94%,显著高于强脉冲光治疗组的44.16%(P<0.05)。治疗3次后,两组患者的红斑程度显著改善,强脉冲光联合30%甘醇酸治疗组患者CEAS评分为(1.78±1.133)分,显著低于强脉冲光治疗组CEAS评分(2.18±1.180)分(t=2.045,P=0.043)。强脉冲光联合30%甘醇酸治疗组满意度81.25%高于强脉冲光治疗组满意度71.43%。治疗期间两组患者均未出现明显不良反应。结论强脉冲光联合甘醇酸治疗痤疮后红斑疗效显著,可有效降低红斑程度,安全性高,患者满意度高,具有较高的临床应用价值。

Objective To investigate the clinical efficacy and safety of intense pulsed light combined with glycolic acid in the treatment of erythema postacne.Methods A total of 141 patients with erythema postacne treated with intense pulsed light and intense pulsed light combined with 30%glycine acid in the Department of Dermatology,the First Hospital Affiliated to Army Medical University from August 2019 to May 2023 were retrospectively analyzed.Among them,77 cases were treated with intense pulsed light,and 64 cases were treated with intense pulsed light combined with 30%glycolic acid.The patients were treated once every four weeks for a total of three times.After treatment,the clinical efficacy,clinician erythema Assessment Scale score,satisfaction score and adverse reactions of the two groups were compared.Results The total clinical effective rate of intense pulsed light combined with 30%glycolic acid treatment group was 60.94%,which was significantly higher than 44.16%of intense pulsed light treatment group(P<0.05).After three courses of treatment,the degree of erythema in the two groups was significantly improved.The ceas score of the intense pulsed light combined with 30%glycolic acid treatment group was(1.78±1.133),which was significantly lower than that of the intense pulsed light treatment group(2.18±1.180)(t=2.045,P=0.043).The satisfaction of intense pulsed light combined with 30%glycolic acid treatment group was 81.25%,which was higher than 71.43%of intense pulsed light treatment group.No obvious adverse reactions occurred in the two groups during the treatment.Conclusions Intense pulsed light combined with glycolic acid in the treatment of erythema postacne has significant curative effect,which can effectively reduce the degree of erythema.The treatment has high safety,patient satisfaction,and high clinical application value.