肿瘤原位荧光标记技术设计和探索虚拟仿真实验

Virtual Simulation Experiment for the Design and Exploration of Tumor in Situ Fluorescence Labeling Technology

原位荧光成像技术为细胞和活体水平生化信息获取提供了强有力的手段,基于固态发光荧光探针的长时间原位标记技术能应用于精准成像与手术导航肿瘤切除。但该科研实验存在周期长、成本高、消耗大等困难,无法引入本科教学。采用U3D三维虚拟现实技术平台将该最新研究成果转化为“肿瘤原位荧光标记技术设计和探索虚拟仿真实验”,通过37步交互操作和基于重要科学问题的探究式教学,培养学生动手能力、科学思维和创新意识,实现科学素养和科研价值观的引导。

In situ fluorescence imaging technology offers an efficacious method for garnering biochemical information at cellular and organismal scales.Prolonged in situ labeling techniques,using solid-state fluorescent probes,are particularly suited for precise imaging and surgical navigation during tumor resections.However,the inherent challenges,including extended research cycles,high costs,and substantial resource utilization,often preclude their inclusion in undergraduate teaching.To surmount these obstacles,we transformed the latest research findings into a“virtual simulation experiment of tumor in situ fluorescent labeling technology design and exploration”utilizing the U3D three-dimensional virtual reality technology platform.Through an interactive 37-step operation and exploratory teaching approach centred on crucial scientific issues,we aim to hone students’practical skills,foster scientific thinking and innovative awareness,actively guide the development of their scientific literacy,and instil values pertinent to scientific research.