卡波姆隔离凝胶联合干扰素治疗女性生殖道高危HPV感染及相关疾病的疗效观察

Clinical efficacy of carbomer isolation gel combined with interferon in the treatment of high-risk human papilloma virus infection and related diseases in female reproductive tract

目的探讨卡波姆隔离凝胶联合干扰素治疗女性生殖道高危人乳头状瘤病毒(HPV)感染及相关疾病的临床疗效。方法前瞻性选取2021年8月至2022年10月于我院妇科就诊的300例女性生殖道高危HPV感染患者为研究对象,按照随机数字表法分为研究组(150例)和对照组(150例)。对照组采用干扰素治疗,研究组采用卡波姆隔离凝胶联合干扰素治疗。比较两组患者的一般资料、用药后的临床效果,以及治疗前后的炎症因子、免疫指标水平及阴道微生态情况。结果两组患者的平均年龄、已婚率等一般资料比较无显著性差异(P>0.05)。治疗后,研究组总有效率[96.67%(145/150)]显著高于对照组[85.33%(128/150)](χ^(2)=11.762,P=0.001)。治疗后,两组患者的肿瘤坏死因子α(TNF-α)和白介素6(IL-6)水平、CD8^(+)T细胞比例、Nugent评分、阴道分泌物pH值均显著低于治疗前(P<0.05),CD3^(+)T细胞比例、CD4^(+)T细胞比例、CD4^(+)/CD8^(+)比值均显著高于治疗前(P<0.05),且研究组治疗后的变化比对照组均更为显著(P<0.05)。结论卡波姆隔离凝胶联合干扰素治疗女性生殖道高危HPV感染及相关疾病的临床疗效显著优于单独应用干扰素治疗;患者的炎症指标、免疫指标和阴道微生态情况均得到了明显改善。

Objective:To explore the clinical efficacy of carbomer isolation gel combined with interferon in the treatment of high-risk human papilloma virus(HPV)infection and related diseases in female reproductive tract.Methods:A total of 300 women with high-risk HPV infection in female reproductive tract were prospectively recruited between August 2021 and October 2022 in Department of Obstetrics and Gynecology,Lishui District People’s Hospital.The patients were divided into the study group(150 cases)and the control group(150 cases)according to a computer-generated table of random numbers.Patients in the control group were treated with interferon and those in the study group were treated with carbomer isolation gel combined with interferon.The basic characteristics,clinical effects,and inflammatory factors,immune index levels and vaginal microecology before and after treatment were compared between the two groups.Results:There were no significant differences in the average age and the number of married women between the two groups(P>0.05).After treatment,the total effective rate of the study group[96.67%(145/150)]was significantly higher than that of the control group[85.33%(128/150)](χ^(2)=11.762,P=0.001).In addition,the levels of tumor necrosis factorα(TNF-α)and interleukin 6(IL-6),as well as the proportion of CD8^(+)T cells,Nugent score and pH value of vaginal secretion in the two groups were significantly lower than those before treatment(P<0.05),while the proportions of CD3^(+)T cells and CD4^(+)T cells as well as the ratio of CD4^(+)/CD8^(+)in the study group were significantly higher than those before treatment(P<0.05).The changes in the study group after treatment were more significant than those in the control group(P<0.05).Conclusions:The clinical efficacy of carbomer isolation gel combined with interferon in the treatment of high-risk HPV infection and related diseases in female reproductive tract could be better than that of interferon alone.The anti-inflammatory and immune function and vaginal microecology of the patients were significantly improved.