淋巴细胞胞质蛋白2在恶性肿瘤发生与发展过程中的免疫调节机制

The Immune Regulatory Mechanism of Lymphocyte Cytoplasmic Protein 2(LCP2)in the Occurrence and Development of Malignant Tumors

淋巴细胞胞质蛋白2(lymphocyte cytosolic protein 2,LCP2)是一种衔接蛋白质,在T细胞受体信号通路中扮演重要角色,激活下游信号因子以完成机体的免疫应答过程。LCP2也在恶性肿瘤的发生发展与转移中发挥重要作用,其高表达会导致不良的预后效果,降低患者生存率,其具体作用机制涉及多条信号通路。本文不仅对LCP2的分子结构以及基本功能进行了介绍,而且重点综合评述了LCP2通过参与NF-κB、MAPK、JAK/STAT以及PD-1/PD-L1信号通路调控恶性肿瘤发生与发展的分子机制。总结了LCP2作为肿瘤治疗靶点的潜在作用,为将来用于相关疾病的诊断、治疗和标志物筛选等提供理论基础和参考依据。

Lymphocyte cytoplasmic protein 2(LCP2)is an adaptor protein that participates in the T cell receptor signal transduction pathway through activating downstream signaling factors to complete the immune response.LCP2 also plays an important role in the occurrence,development and metastasis of malignant tumors.The high expression of LCP2 leads to adverse prognostic effects and reduces patient survival rates.The specific mechanisms of these reactions involve multiple signaling pathways.Here we introduce the structure and basic functions of LCP2,and review the important roles that LCP2 plays in the occurrence and development of malignant tumors through participating in NF-κB,MAPK,JAK/STAT,and PD-1/PD-L1 signaling pathways.The potential role of LCP2 as a tumor treatment target was also discussed for providing a theoretical basis and reference for the diagnosis,treatment,and biomarker screening of relevant diseases.