MiRNA和lncRNA在非小细胞肺癌中作用的研究进展

Research Progress on the Roles of miRNA and lncRNA in Non-Small Cell Lung Cancer

非小细胞肺癌(non small-cell lung cancer,NSCLC)是最常见的肺癌类型,大约80%至85%的肺癌是非小细胞肺癌。非小细胞肺癌早期诊断手段有限,缺乏有效的生物标志物,晚期手术难度大且复发率高。miRNA(microRNA)和lncRNA(long non-coding RNA)是两类重要的基因表达调控分子,广泛参与了生物体的各种生命活动,并与多种疾病密切相关。许多miRNA和lncRNA在非小细胞肺癌中差异表达显著,在肿瘤的发生发展过程中发挥重要的调控作用,具有成为非小细胞肺癌生物标志物的潜力。本文对miRNA和lncRNA在非小细胞肺癌发生发展中调控作用的研究进展作一综述。

Non-small cell lung cancer(NSCLC)is the most common type of lung cancer,accounting for approximately 80%~85%of all lung cancer cases.The early diagnosis of NSCLC presents challenges due to limited diagnostic methods and lack of effective biomarkers.Furthermore,surgical intervention in the advanced stages of NSCLC is difficult,and the recurrence rate is high.MicroRNA(miRNA)and long non-coding RNA(lncRNA)are two crucial types of gene expression regulatory molecules that are widely involved in various biological activities and closely associated with multiple diseases.Quantities of miRNAs and lncRNAs exhibit significant differential expression in NSCLC and play crucial regulatory roles in the occurrence and development of tumors,thereby holding potential as biomarkers for NSCLC.This article reviews the research progress on the regulatory roles of miRNAs and lncRNAs in the occurrence and development of NSCLC.