基于数据挖掘探讨大椎临床应用规律

Discussion on clinical application of Dazhui acupoint based on data mining

目的基于数据挖掘探讨大椎主治优势病症与配伍规律。方法检索2012年1月1日-2022年8月15日中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(重庆维普)、中国生物医学文献数据库(CBM)和PubMed发表的大椎相关文献, 归纳其主治病症和腧穴配伍, 采用Gephi 0.9.5软件进行复杂网络分析, 对比大椎单穴和配伍主治优势病症;采用SPSS Modeler 18.0软件, 基于Apriori算法对腧穴组合进行关联规则分析;采用SPSS Statistics 26.0软件对高频腧穴进行聚类分析。结果纳入文献722篇, 涉及处方732首, 单穴主治优势病症为颈椎病、痤疮、和感冒;配伍主治优势病症为颈椎病、变应性鼻炎、缺血性卒中后遗症等14类;经脉配伍以足太阳膀胱经为首, 阳经频次高于阴经;腧穴配伍以下合穴、背俞穴、八会穴等特定穴为主, 高频腧穴有肺俞、百会、风池、足三里等33个穴, 得到4系8类大椎配伍组合。结论大椎广泛应用于内科病症, 长于呼吸系统疾病、神经系统疾病及椎动脉型颈椎病, 倾向于特定穴多重配伍与聚类组合灵活运用。

Objective To discuss dominant symptoms and compatibility rules of Dazhui(GV14)based on data mining.Methods Literature related to Dazhui(GV14)was retrieved from CNKI,Wangfang,VIP,China Biomedical Literature Database(CBM)and Pubmed databases from January 1,2012 to August 15,2022,and the main symptoms of Dazhi(GV14)and the compatibility of acupoints were summarized.Gephi 0.9.5 software was used for complex network analysis to compare the treatment for dominant symptoms with single acupoint of Dazhi(GV14)and the compatibility of the acupoint.SPSS Modeler 18.0 software was used to analyze the association rules of acupoint combination based on Apriori algorithm.The clustering analysis of high frequency acupoints was carried out by SPSS Statistics 26.0 software.Results A total of 722 articles were included,involving 732 prescriptions.The dominant symptoms of single acupoint were cervical spondylosis,acne,and cold;the treatment for dominant symptoms with compatibility included 14 types,such as cervical spondylosis,allergic rhinitis,ischemic stroke sequelae.The meridian compatibility was dominated by bladder meridian,and the frequency of yang meridians was higher than yin meridians.The compatibility of specific acupoints such as Xiahe acupoint,Beishu acupoint and Bahui acupoint were the main acupoints,and the high frequency acupoints were 33 acupoints such as Feishu(BL13),Baihui(GV20),Fengchi(GB20)and Zusanli(ST36),obtaining 4 series and 8 types of compatible combinations of Dazhui(GV14).Conclusions Dazhui(GV14)is widely used in the treatment of internal diseases,such as respiratory diseases,nervous system diseases and vertebral artery type of cervical spondylosis.It tends to be flexibly used with multiple compatibility and clustering combination of specific acupoints.