间歇性禁食及肠道微生物群在脑卒中防治中的研究进展

Research progress of intermittent fasting and intestinal microbiota in stroke prevention and treatment

脑卒中是临床最常见的急性脑血管病,包括缺血性卒中与出血性卒中。脑卒中的危险因素与高血压、糖尿病、血脂异常、动脉粥样硬化、肥胖等慢性疾病有关,生活方式与饮食习惯改善成为预防脑卒中的重要手段。研究表明间歇性禁食作为一种饮食干预的手段,可以影响肠道微生物群,且在减重、改善糖脂代谢、控制高血压、延缓动脉粥样硬化方面效果明显,对脑卒中后缺血再灌注损伤也具有保护作用。本综述旨在总结目前国内外相关研究成果,阐述间歇性禁食对肠道微生物群构成、代谢的影响,及间歇性禁食与肠道微生物群在防治脑卒中的作用机制,为推进将间歇性禁食纳入脑卒中防治健康教育提供理论依据。

Stroke is the most common acute cerebrovascular disease in clinical practice,including ischemic stroke and hemorrhagic stroke.Risk factors of stroke are related to chronic diseases such as hypertension,diabetes,dyslipidemia,atherosclerosis,obesity.Lifestyle and dietary improvement have become an important means to prevent stroke.Studies have shown that intermittent fasting,as a means of dietary intervention,can affect the intestinal microbiota,and it has obvious effects on weight loss,improvement of glucose and lipid metabolism,control of hypertension,delay atherosclero-sis,and intermittent fasting also has a protective effect on ischemia-reperfusion injury after stroke.This review aims to summarize the current related research results at home and abroad,elaborate the effects of intermittent fasting on the composition and metabolism of intestinal microbiota,and the mechanism of intermittent fasting and intestinal microbiota in the prevention and treatment of stroke,and provide a theoretical basis for promoting the intermittent fasting into stroke prevention and treatment health education.