针刺调控缺血性卒中后神经元线粒体的作用机制研究进展

Advances of research on mechanisms of acupuncture underlying improvement of ischemic stroke by regulating neuronal mitochondria

针刺治疗缺血性卒中(IS)具有显著疗效。针刺治疗IS的作用与调控线粒体功能具有密切的联系。本文从线粒体结构、线粒体功能、线粒体质量控制、线粒体相关的细胞凋亡通路4个方面对线粒体在针刺治疗IS中的作用与相关机制进行综述,为针刺通过调控神经元线粒体治疗IS提供理论依据,为今后深入开展相关研究提供参考。

Acupuncture has a positive effect in the treatment of ischemic stroke(IS). A number of studies have confirmed that the role of acupuncture in the treatment of IS, which is closely related to its functions of regulating mitochondrial functions. In the present article, we review the mechanisms of acupuncture underlying improvement of mitochondria in the treatment of IS from 4 aspects: 1) protecting mitochondrial structure integrity, 2) regulative effect on mitochondrial functional activities, including regulating energy metabolism, reducing oxidative stress, suppressing calcium overload, and regulating mitochondrial membrane potential changes, 3) regulating mitochondrial quality control system, including promoting mitochondrial biosynthesis, regulating mitochondrial dynamics and apoptosis, and 4) regulating mitochondria-related apoptosis pathways. All of these may provide a theoretical basis for acupuncture in the treatment of IS and a reference for further research.