摘要
In a recent study published in Nature,Sun et al.(2023)discovered that targeting TANK-binding kinase 1(TBK1)can successfully overcome resistance to immune checkpoint blockade(ICB)treatment and the study revealed its potential mechanism.The authors provided evidence that the disruption of TBK1 signal enhances the blockade of programmed cell death protein-1(PD-1)and promotes anti-tumor immunity in the tumor microenvironment(TME).Tumor cells rely on Janus kinase(JAK)and signal transducer as well as activator of transcription(STAT)signals to elicit an immune response by perceiving tumor necrosis factorα(TNF-α)and interferon-γ(IFN-γ),resulting in receptor-interacting protein kinase(RIPK)-caspase-mediated cell death in tumor cells(Figure 1).
基金
This work was supported by the National Key Research and Development Program of China(2021YFA1101000,2022YFA1105200)
the National Natural Science Foundation of China(82041009,32125016,U20A20393,31925013)
Zhejiang Natural Science Fund(LD19C070001)
Gusu Innovation Leading Talent Program(ZXL2022505).