表观遗传机制在原发性高血压中的作用及针刺干预研究

Role of Epigenetic Mechanisms in Essential Hypertension and Study on Acupuncture Intervention

检索近年来国内外相关文献,研究表观修饰对原发性高血压的调控机制以及针刺通过表观遗传修饰干预原发性高血压的现状。探讨表观遗传学通过DNA甲基化、组蛋白、非编码RNA及m6A修饰等方面调控原发性高血压的发生与发展。目前,针刺降压被临床广泛应用,但针刺基于表观遗传机制降压的研究较少且仍处于初级阶段。本研究以表观遗传视角探究针刺降压机制,以期为针刺降压提供更多分子生物学依据,为靶向治疗原发性高血压提供新方向、新视角。

The relevant literature at home and abroad in recent years were retrieved in terms of regulatory mechanisms of epigenetic modification on essential hypertension and the current situation and prospect of acupuncture intervention for essential hypertension through epigenetic modification.It is explored that epigenetics regulates the occurrence and development of essential hypertension through DNA methylation,histone,non-coding RNA,and m6A modification.At present,acupuncture for hypotension is widely used in clinic,but the research on acupuncture for hypertension based on epigenetic mechanism is less and still in the initial stage.This study explored the mechanisms of acupuncture for hypertension from the perspective of epigenetics in order to provide more molecular biological bases and to provide a new direction and perspective for targeted treatment of essential hypertension.