细胞焦亡评分在胃癌治疗和预后评估中的应用

Application of pyroptosis score in the treatment and prognosis evaluation of gastric cancer

细胞焦亡是一种由炎症小体介导的促炎程序性细胞死亡,可通过不同的途径影响胃癌的发生、发展。细胞焦亡对于肿瘤具有双重作用:一方面,炎症小体介导的炎症反应可能参与了早期肿瘤的形成和发展;另一方面,药物通过激活炎症小体和细胞焦亡通路抑制肿瘤细胞的增殖、侵袭和转移等恶化过程。近年来已发现多种基于细胞焦亡治疗胃癌的药物,可通过促进继发焦亡途径、调控NOD样受体热蛋白结构域相关蛋白3(NOD-like receptor family pyrin domain containing 3,NLRP3)炎症小体和抑制caspase‐1等方式来抑制胃癌。建立细胞焦亡评分模型可以预测胃癌患者的预后,大部分细胞焦亡评分模型显示高焦亡水平的胃癌患者具有较好的预后和较长的总生存期。细胞焦亡评分还可用于预测胃癌患者对免疫疗法的反应,以及筛选潜在的抗胃癌药物。深入了解细胞焦亡影响胃癌进展的潜在机制,以及细胞焦亡评分在胃癌治疗和预后评估中的作用,有助于为胃癌的治疗寻找新的有效方法。

Pyroptosis is a kind of proinflammatory programmed cell death mediated by inflammasome.It affects the occurrence and development of gastric cancer through different ways,showing dual effects.On the one hand,inflammasome-mediated inflammatory response is highly likely to participate in the formation and development of early tumors;on the other hand,drugs can inhibit the deterioration process of tumor proliferation,invasion and metastasis through activating the pathways of inflammasome and pyroptosis.Recently,many agents based on pyroptosis have been found to inhibit gastric cancer by promoting the secondary pyroptosis pathway,regulating NOD-like receptor family pyrin domain containing 3(NLRP3)inflammasome and inhibiting caspase-1.The establishment of cell pyrodeath models can predict the prognosis of gastric cancer patients.Most of the models show that gastric cancer patients with high pyroptosis level have better prognosis and longer overall survival.Pyroptosis scores can also be used to predict the response of gastric cancer patients to immunotherapy and to screen potential anti-gastric cancer drugs.Therefore,in-depth understanding of the potential mechanism of pyroptosis affecting the progression of gastric cancer and the role of pyroptosis score in the treatment and prognosis assessment of gastric cancer will be helpful to find a new and effective method for the treatment of gastric cancer.