炎症与肿瘤微环境

Inflammation and tumor microenvironment

炎症与肿瘤之间存在联系。炎症是肿瘤的标志之一,影响肿瘤的进展、向恶性表型的转变以及肿瘤化学治疗药物的疗效,肿瘤微环境通过多种特定因素和信号机制影响肿瘤的生物学特性。炎症与肿瘤微环境之间相互作用,炎症通过诱导免疫抑制来影响肿瘤微环境,急性炎症通过产生抗肿瘤免疫反应来抑制肿瘤。本综述从肿瘤微环境的组分、炎症小体、细胞因子和非编码RNA等方面出发,阐述炎症如何通过影响肿瘤微环境,从而影响肿瘤的进展及治疗。炎症因子在调节炎症反应和免疫应答发挥重要的作用,同时它在肿瘤微环境中通过多种途径影响肿瘤的发展,它可以通过抑制免疫细胞的活性,使肿瘤逃避免疫监视,从而促进肿瘤细胞的增殖和转移。炎症也会引起氧化应激,生成活性氧和活性氮等氧化剂,这些氧化剂会损害核酸、蛋白质和脂质,诱导基因的突变和肿瘤转化。此外,非编码RNA在肿瘤微环境中扮演重要角色,对肿瘤和炎症起调控作用。它们通过多种途径参与调控肿瘤的发生、发展和炎症的过程,也参与调节炎症诱导的肿瘤或肿瘤相关的炎症,以及调节肿瘤微环境、炎症因子和免疫细胞之间的相互作用。因此,更深入地了解炎症与肿瘤微环境之间的相互作用与肿瘤发生、发展之间的联系,可以为肿瘤的治疗提供理论基础和策略。

There is a connection between inflammation and cancer.Inflammation is one of the hallmarks of cancer,affecting tumor progression,transition to a malignant phenotype,and the efficacy of tumor chemotherapy.The tumor microenvironment impacts the biological characteristics of tumors through various specific factors and signaling mechanisms.The interaction between inflammation and the tumor microenvironment involves inflammation affecting the tumor microenvironment by inducing immune suppression,while acute inflammation promotes tumor suppression by producing anti-tumor immune responses.This review elaborates on how inflammation affects the tumor microenvironment and thus affects the progression and treatment of tumors,starting from the components of the tumor microenvironment,inflammasomes,cytokines,non-coding RNAs,and other aspects.Inflammatory factors play an important role in regulating inflammatory responses and immune reactions,and they also affect the development of tumors through various pathways in the tumor microenvironment.In addition,non-coding RNAs play an important role in the tumor microenvironment,regulating tumors and inflammation.They are involved in regulating the occurrence,development of tumors,the process of inflammation,as well as regulating inflammation-induced cancer or tumor-related inflammation,and the interaction between the tumor microenvironment,inflammatory factors,and immune cells.Therefore,gaining a deeper understanding of the interaction between inflammation and the tumor microenvironment and its connection to the occurrence and development of cancer can provide a theoretical basis for combating tumors and finding new therapeutic strategies.