男性酒依赖患者合并贫血影响因素分析及预测模型构建

Analysis of influencing factors and construction of prediction model for anemia in male alcohol dependent patients

目的:探讨男性酒依赖患者合并贫血影响因素,并构建相应预测模型。方法:回顾性收集155例男性酒依赖患者临床资料,包括一般临床特征、饮酒情况以及实验室指标等。根据血红蛋白是否<130g/L(男性)将患者分为贫血组(n=63)与非贫血组(n=92),通过单因素及逐步多因素Logistic回归分析筛选男性酒依赖患者合并贫血的影响因素,并建立预测模型,最后采用ROC曲线评估模型预测能力。结果:155例男性酒依赖患者中有63例合并贫血,发生率为40.65%。逐步多因素Logistic回归分析显示,年龄、饮酒量、低钾血症、低蛋白血症、低淋巴细胞与单核细胞比值(LMR)均是男性酒依赖患者合并贫血的影响因素(P均<0.05)。Logistic回归方程为Logit(p)=-9.421+0.055×年龄+0.046×饮酒量+1.386×低钾血症+1.950×低蛋白血症+1.003×低LMR。联合预测因子曲线下面积为0.815,灵敏度为77.8%,特异度为75.0%%,截断值为0.382。结论:年龄、饮酒量、低钾血症、低蛋白血症、低LMR是男性酒依赖患者合并贫血的影响因素;本研究构建预测模型可为临床早期评估男性酒依赖患者合并贫血提供借鉴。

Objective:To explore the influencing factors of anemia in male patients with alcohol depend-ence,and to construct related prediction model.Method:The clinical data of 155 male patients with alcohol dependence were retrospectively collected,including general clinical characteristics,drinking status and experi-mental indicators.According to whether hemoglobin<130 g/L(male),the patients were divided into anemia group(n=63)and non-anemia group(n=92).Univariate and stepwise multivariate logistic regression analy-sis was used to screen the influencing factors of anemia in male alcohol dependence patients,and the prediction model was established.ROC curve was used to evaluate the predictive ability of the model.Results:Among 155 male patients with alcohol dependence,63 cases were complicated with anemia,and the incidence was 40.65%.Stepwise multivariate logistic regression analysis showed that age,alcohol consumption,hypokalemia,hypoproteinemia and low Lymphocyte-to-Monocyte Ratio(LMR)were the influencing factors of anemia in male patients with alcohol dependence(all P<0.05).Logistic regression equation was Logit(P)=-9.421+0.055×age+0.046×alcohol consumption+1.386×hypokalemia+1.950×hypoproteinemia+1.003×low LMR.The area under curve of the combined predictor was 0.815,the sensitivity was 77.8%,the specificity was 75.0%,and the cut-off value was 0.382.Conclusion:Age,alcohol consumption,hypokalemia,hypoproteine-mia and low LMR are the influencing factors of anemia in male patients with alcohol dependence;The prediction model constructed in this study can provide reference for early clinical evaluation of anemia in male alcohol de-pendent patients.