发作性睡病共病精神分裂症1例报告并文献复习

Narcolepsy comorbidity with schizophrenia:a case report and literature review

提高对发作性睡病共病精神分裂症的临床特征和诊断治疗的认识。分析1例发作性睡病共病精神分裂症患者的临床资料并复习相关文献。本例以日间嗜睡、夜间睡眠障碍伴发典型幻觉、妄想等精神病性症状为主要临床表现,多次睡眠潜伏期试验显示平均入睡潜伏期1.4min,出现4次睡眠始发REM睡眠现象,符合发作性睡病共病精神分裂症诊断标准,经药物治疗后症状缓解。发作性睡病共病精神分裂症临床罕见,应提高对此类疾病诊断意识,在药物使用方面要权衡利弊,力求两者兼顾的治疗方案。

To improve the understanding of clinical features,diagnosis and treatment of narcolepsy co-morbidity with schizophrenia.The clinical information of a case of narcolepsy comorbidity with schizophrenia was analyzed and the related literatures were reviewed.In this case,the main clinical manifestations included exces-sive daytime sleepiness(EDS),nocturnal sleep disturbance,and typical psychotic symptoms such as hallucina-tions and delusions.Multiple sleep latency test(MSLT)showed that mean sleep latency was 1.4 min and showed 4 sleep onset rapid eye movement periods(SOREMPs).The finding was extremely consistent with the diagnosis criteria for narcolepsy comorbidity with schizophrenia,and finally this case's symptoms were relieved after pharmacotherapy.Considering the rarity of narcolepsy comorbidity with schizophrenia,it is necessary to im-prove the diagnosis awareness of this kind of disease,and to balance the advantages and disadvantages in drug use,so as to strive for the effective management of both.