PCT、hs-CRP结合CEA检测用于肺癌鉴别诊断的价值

Value of PCT,hs-CRP combined with CEA detection in differential diagnosis of lung cancer

目的研究肺癌诊断中应用肿瘤标志物癌胚抗原(CEA)与炎性因子降钙素原(PCT)、超敏C反应蛋白(hs-CRP)检测的效果。方法以平顶山市中医医院2020年1月至2022年12月收治的200例疑似肺癌患者及同期在我院进行体检的100例健康志愿者为研究对象,所有患者采集血样检测相关肿瘤标志物与炎性因子水平。结果200例疑似肺癌患者的病理检查结果显示,肺癌患者100例,肺良性病变患者100例。肺癌患者、肺良性病变患者与健康志愿者以及非小细胞肺癌与小细胞肺癌患者CEA水平与PCT、hs-CRP水平比较差异有统计学意义(P<0.05)。100例肺癌患者中,CEA、PCT、hs-CRP阳性检出率分别为69.00%、61.00%、54.00%;100例肺良性病变患者中,CEA、PCT、hs-CRP阳性检出率分别为9.00%、47.00%、40.00%;100例健康志愿者中,CEA、PCT、hs-CRP阳性检出率分别为3.00%、0.00%、1.00%,三组CEA、PCT、hs-CRP阳性检出率比较有统计学意义(P<0.05)。以病理检查为金标准,炎性因子联合肿瘤标志物的诊断灵敏度、特异度、准确率85.00%、96.00%、92.33%。结论CEA联合PCT、hs-CRP检测诊断肺癌具有较高的灵敏度、特异度及准确率。

【Objective】To study the effect of the detection of tumor marker carcinoembryonic antigen(CEA),inflammatory factors procalcitonin(PCT)and high-sensitivity C-reactive protein(hs-CRP)in the diagnosis of lung cancer.【Methods】Totally 200 patients with suspected lung cancer admitted to Pingdingshan Hospital of Traditional Chinese Medicine from January 2020 to December 2022 and 100 healthy volunteers who underwent physical examination in our hospital at the same time were taken as research objects.Blood samples were collected from all patients to detect the levels of tumor markers and inflammatory factors.【Results】The pathological examination results of 200 suspected lung cancer patients showed that there were 100 lung cancer patients and 100 patients with benign lung lesions.There were significant differences in CEA levels,PCT and hs-CRP levels among lung cancer patients,benign lung disease patients,healthy volunteers,and non-small cell lung cancer and small cell lung cancer patients(P<0.05).Among 100 lung cancer patients,the positive detection rates of CEA,PCT,and hs-CRP were 69.00%,61.00%,and 54.00%,respectively.Among 100 patients with benign lung lesions,the positive detection rates of CEA,PCT,and hs-CRP were 9.00%,47.00%,and 40.00%,respectively.Among 100 healthy volunteers,the positive detection rates of CEA,PCT,and hs-CRP were 3.00%,0.00%,and 1.00%,respectively.The positive detection rates of CEA,PCT,and hs CRP among the three groups were statistically significant(P<0.05).Using pathological examination as the gold standard,the diagnostic sensitivity,specificity,and accuracy of inflammatory factors combined with tumor markers are 85.00%,96.00%,and 92.33%.【Conclusion】CEA combined with PCT and hs-CRP detection has high sensitivity,specificity,and accuracy in the diagnosis of lung cancer.