妈咪爱和蒙脱石散联合治疗对腹泻患儿大便、血常规恢复正常时间的影响分析

Analysis of the influence of combined treatment of Medilac-vita and montmorillonite powder on the recovery time of stool and blood routine in children with diarrhea

目的分析枯草杆菌二联活菌颗粒(商品名:妈咪爱)和蒙脱石散联合治疗对腹泻患儿大便、血常规恢复正常时间的影响。方法87例腹泻患儿,根据治疗方法的不同分为研究组(44例)与参考组(43例)。研究组采用妈咪爱和蒙脱石散联合治疗,参考组采用蒙脱石散治疗。比较两组患儿临床疗效,大便(大便次数、大便性状恢)、血常规恢复正常时间及症状(腹痛、呕吐、发热)消退时间,炎症因子、免疫指标改善情况。结果研究组患儿大便次数、大便性状、血常规恢复正常时间以及腹痛、呕吐、发热消退时间分别为(2.23±0.13)、(3.28±0.18)、(2.58±0.22)、(1.07±0.05)、(1.18±0.08)、(1.91±0.11)d,均显著短于参考组的(3.24±0.17)、(4.44±0.29)、(4.99±0.45)、(2.24±0.09)、(2.75±0.17)、(2.92±0.24)d(P<0.05)。治疗后,两组患儿白细胞介素-2、白细胞介素-10、免疫球蛋白G、免疫球蛋白A水平均较治疗前显著改善,且研究组患儿白细胞介素-2(41.65±3.64)pg/ml、白细胞介素-10(75.64±6.87)pg/ml、免疫球蛋白G(16.88±2.18)g/L、免疫球蛋白A(1.69±0.34)g/L均显著优于参考组的(59.92±5.09)pg/ml、(54.35±5.24)pg/ml、(11.86±1.26)g/L、(1.28±0.22)g/L(P<0.05)。研究组患儿总有效率97.73%显著高于参考组的83.72%(P<0.05)。结论妈咪爱和蒙脱石散联合治疗腹泻患儿能有效缩短大便、血常规恢复正常时间及各项症状消退时间,提升总体疗效,改善患儿炎症因子和免疫功能。

Objective To analyze the influence of combined treatment of live combined bacillus subtilis and enterococcus faecium granules with multivitamines(trade name:Medilac-vita)and montmorillonite powder on the recovery time of stool and blood routine in children with diarrhea.Methods 87 children with diarrhea were divided into a study group(44 cases)and a reference group(43 cases)according to different treatment methods.The study group was treated with Medilac-vita and montmorillonite powder,and the reference group was treated with montmorillonite powder.Both groups were compared in terms of clinical efficacy,stool(recovery of frequency of stool and stool property),recovery time of blood routine,time to remission of symptoms(abdominal pain,vomiting,fever),inflammatory factors,immune indicators improvement.Results In the study group,the time to recovery of frequency of stool and stool property were(2.24±0.09),(2.75±0.17)and(2.92±0.24)d,the time to remission of abdominal pain,vomiting and fever were(3.24±0.17),(4.44±0.29)and(4.99±0.45)d,which were significantly shorter than(2.23±0.13),(3.28±0.18),(2.58±0.22)d and(1.07±0.05),(1.18±0.08),(1.91±0.11)d in the reference group(P<0.05).After treatment,the levels of interleukin-2,interleukin-10,immunoglobulin G and immunoglobulin A were significantly improved in both groups compared with those before treatment;and the study group had interleukin-2 of(41.65±3.64)pg/ml,interleukin-10 of(75.64±6.87)pg/ml,immunoglobulin G of(16.88±2.18)g/L and immunoglobulin A of(1.69±0.34)g/L,which were significantly higher than(59.92±5.09)pg/ml,(54.35±5.24)pg/ml,(11.86±1.26)g/L and(1.28±0.22)g/L in the reference group(P<0.05).The total effective rate of the study group was 97.73%,which was significantly higher than 83.72%of the reference group(P<0.05).Conclusion The combination of Medilac-vita and montmorillonite powder in the treatment of children with diarrhea can effectively shorten the recover time of stool and blood routine and the time to remission of various symptoms,improve the overall curative effect,and improve the inflammatory factors and immune function of children.