炎症标志物与肺癌伴焦虑抑郁、睡眠障碍、疲乏的相关性研究进展

Research Progress on Correlation of Inflammatory Markers withAnxiety, Depression, Sleep Disorders and Fatigue in Lung CancerPatients

肺癌是全球范围内发病率和死亡率较高的恶性肿瘤,严重威胁着人们的生命健康。肺癌患者在治疗期间还会出现严重的心理应激反应,伴随不同程度的焦虑抑郁、睡眠障碍、疲乏等症状,并与肺癌的发生、进展、转归互为恶性循环。而干扰素、促炎因子、肿瘤坏死因子等炎症标志物不仅促进肺癌的生长和扩散,还会影响患者下丘脑-垂体-肾上腺轴功能,改变5-羟色胺等神经递质代谢,诱发或加重焦虑抑郁、睡眠障碍、疲乏,可提示患者预后不良。全文分析炎症标志物与肺癌患者伴焦虑抑郁、睡眠障碍、疲乏之间的相关性以及研究进展。

Lung cancer is the most common malignant disease globally with high incidence and mortality.Lung cancer patients frequently have substantial psychological stress during treatment,manifesting varying degrees of anxiety,depression,sleep disorders and fatigue,which cause a vicious cycle influencing disease progression,and prognosis of patients.Various pro-inflammatory factors not only can promote tumor growth and induce metastasis of lung cancer,but also can disrupt normal function of hypothalamic-pituitary-adrenal axis and interfere neurotransmitter metabolism to trigger or intensify anxiety,depression,sleep disorders and fatigue,leading to unfavorable prognosis of patients.This paper reviews the latest research progress on the correlation between inflammatory markers and lung cancer-associated anxiety,depression,sleep disorders,fatigue.