西酞普兰结合泮托拉唑和伊托必利治疗反流性食管炎的效果及对患者临床症状的影响

Effect of citalopram combined with pantoprazole and itopride in the treatment reflux esophagitis and its influence on clinical symptoms of patients

目的分析西酞普兰结合泮托拉唑和伊托必利治疗反流性食管炎(RE)的效果。方法选取2020年3月至2022年3月我院收治的100例RE患者为研究对象,以随机数字表法将其为对照组和观察组,各50例。两组患者在住院期间均需要采取对症治疗,在此基础上,对照组采取泮托拉唑和伊托必利治疗,观察组采取西酞普兰结合泮托拉唑和伊托必利治疗。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的胃动素水平高于对照组,胃泌素及白细胞介素-17(IL-17)水平低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的反酸、胸骨后烧痛及烧心积分均低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的焦虑自评量表(SAS)、抑郁自评量表(SDS)评分均低于对照组,差异具有统计学意义(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论西酞普兰结合泮托拉唑和伊托必利治疗RE取得了理想的应用效果,能够缓解患者的焦虑、抑郁情绪,减轻心理因素对治疗的影响,可以提高临床疗效,显著改善临床症状,并且具有较高的用药安全性,值得临床推广。

Objective To analyze the effect of citalopram combined with pantoprazole and itopride in the treatment of reflux esophagitis(RE).Methods A total of 100 patients with RE admitted in our hospital from March 2020 to March 2022 were selected as the research objects,and the patients were divided into control group and observation group by random number table method,with 50 cases in each group.Both groups of patients given symptomatic treatment during hospitalization,on this basis,the control group was treated with pantoprazole and itopride,and the observation group was treated with citalopram combined with pantoprazole and itopride.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the level of motilin in the observation group was higher than that in the control group,and the levels of gastrin and interleukin-17(IL-17)were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the scores of acid reflux,retrosternal burning pain and heartburn in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the scores of Self-Rating Anxiety Scale(SAS)and Self-Rating Depression Scale(SDS)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Citalopram combined with pantoprazole and itopride in the treatment of RE has achieved ideal application effect,which can alleviate the anxiety and depression of patients,reduce the influence of psychological factors on the treatment,improve the clinical efficacy,significantly ameliorate the clinical symptoms,and has high drug safety,which is worthy of clinical promotion.