阿立哌唑联合无抽搐电休克治疗对精神分裂症患者临床疗效及神经营养因子和甲状腺功能的影响

Effects of aripiprazole combined with modified electro convulsive therapy on clinical efficacy and neurotrophic factors and thyroid function in patients with schizophrenia

目的探究阿立哌唑联合无抽搐电休克治疗(MECT)对精神分裂症患者临床疗效及神经营养因子和甲状腺功能的影响。方法选取2021年6月至2022年12月抚州市第三医院收治的60例精神分裂症患者作为观察对象,根据治疗方式不同分为两组,每组30例。常规组给予阿立哌唑治疗,联合组给予阿立哌唑联合MENCT治疗,比较两组临床疗效、治疗前后血清神经营养因子[神经生长因子(NGF)、脑源性生长因子(BDNF)、神经营养因子3(NT-3)]水平和甲状腺功能[游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺素(TSH)]。结果联合组治疗总有效率为93.33%,高于常规组的70.00%,差异有统计学意义(P<0.05)。治疗后,两组血清NGF、BDNF、NT-3水平均明显高于治疗前,且联合组高于常规组,差异有统计学意义(P<0.05)。治疗后,两组血清FT3、FT4水平明显低于治疗前,TSH水平明显高于治疗前,且联合组血清FT3、FT4、TSH水平均高于常规组,差异有统计学意义(P<0.05)。结论阿立哌唑联合MECT治疗精神分裂症的临床效果显著,能有效改善患者临床症状和神经营养因子及甲状腺功能。

Objective To explore the aripiprazole combined with modified electro-convulsive therapy(MECT)on clinical efficacy,neurotrophic factors and thyroid function in patients with schizophrenia.Methods 60 patients with schizophrenic treated in the the Third Hospital of Fuzhou from June 2021 to December 2022 were selected as the observation subjects,and they were divided into two groups according to the different treatment methods,with 30 cases in each group.The routine group were treated with oral aripiprazole,the combined group were treated with aripiprazole com-bined with MECT,the clinical efficacy,andserum neurotrophic factor(nerve growth factor[NGF],brain-derived growth factor[BDNF],neurotrophic factor-3[NT-3])and thyroid function[free triiodothyronine[FT3],free thyroxine[FT4],thyrotropin[TSH])before and after treatment were compared between the two groups.Results The total effective rate in the combined group was 93.33%,which was significantly higher than 70.00%in the rou-tine group,and the difference was statistically significant(P<0.05).After treatment,the levels of serum NGF,BDNF and NT-3 of the two groups were significantly higher than those before treatment,and the combined group were higher than those in the routine group,and the differences were statistically significant(P<0.05).After treatment,the levels of serum FT3 and FT4 of the two groups were significantly lower than those before treatment,and the level of TSH was significantly higher than that before treatment,and the combined group were significantly higher than those in the routine group,and the differences were statistically significant(P<0.05).Conclusion Aripiprazole combined with MECT has significant clinical effect in the treatment of schizophrenia,which can effectively improve clinical symptoms,neurotrophic factors and thyroid function.