4种不同药物治疗精神分裂症的效果分析与经济性评价

Effect analysis and economic evaluation of four different drugs in the treatment of schizophrenia

目的探讨4种不同药物治疗精神分裂症患者的效果与经济性评价。方法回顾性分析2019年1月至2020年1月于江苏省如东县第四人民医院住院及门诊的500例精神分裂症患者的临床资料,根据用药方案分为甲组(n=128)、乙组(n=126)、丙组(n=123)、丁组(n=123)。甲组给予利培酮片(剂量维持于每天2~6mg),乙组给予氯氮平口腔崩解片(剂量维持于每天5~15mg),丙组给予阿立哌唑口崩片(剂量维持于每天10~30mg),丁组给予富马酸奎硫平片(剂量维持于每天150~750mg),比较4组临床疗效、不良反应发生情况及药物成本费用。结果4组治疗总有效率比较差异无统计学意义;4组药物不良反应发生率比较差异无统计学意义;甲组药物成本费用低于乙组、丙组及丁组,差异有统计学意义(P<0.05);乙组、丙组及丁组药物成本费用两两比较差异无统计学意义。结论精神分裂症患者应用利培酮、奥氮平片、阿立哌唑口崩片、富马酸奎硫平片治疗均有显著疗效,其中利培酮药物成本费用最低,临床治疗时需结合患者实际情况合理选择药物。

Objective To investigate the effect and economical evaluation of four different drug treatments in patients with schizophrenia.Methods The clinical data of 500 patients with schizophrenia who were hospitalized and outpatient in the Fourth People's Hospital of Rudong County from January 2019 to January 2020 were retrospectively analyzed,and they were divided into the group A(n=128),the group B(n=126),the group C(n=123),and the group D(n=123)according to the medication regimen.Group A was given risperidone tablets(dose maintained at 2-6 mg ev-ery day),the group B was given clozapine orally disintegrating tablets(dose maintained at 5-15 mg every day),the group C was given aripiprazole oral-ly disintegrating tablets(dose maintained at 10-30 mg every day),and the group D was given quetiapine fumarate tablets(dose maintained at 150-750 mg every day).The clinical efficacy,incidence of adverse reactions,and average drug cost were compared among the four groups.Results There was no statistically significant difference in the total effective rate among the four groups.The drug cost in the group A was lower than that in the group B,the group C and the group D,and the difference was statistically significant(P<0.05);there was no significant difference in the cost among the group B,the group C and the group D in pairwise comparison.Conclusion Risperidone,clozapine orally disintegrating tablets,aripiprazole orally dis-integrating tablets,and quetiapine fumarate tablets have significant curative effects in the treatment of schizophrenia patients,among which risperi-done has the lowest cost,and and reasonable selection of drugs should be combined with the actual situation of patients in clinical treatment.