基于零维碳量子点/二维MoS2混合维异质结晶体管的视觉失忆脉冲光电治疗模拟

0D-carbon-quantum-dots/2D-MoS_(2)mixed-dimensional heterojunction transistor for emulating pulsatile photoelectric therapy of visual amnesic behaviors

失忆症是一种临床常见的疾病,表现为近期记忆的丧失以及获得新记忆能力的全面受损,它严重影响了人类的正常生活.目前,虽然草药干预、蛋白质合成抑制和激素替代可以预防或逆转失忆行为,但这些疗法都相对昂贵且效率低下.本文利用一种先进的光电协同脉冲疗法,基于零维碳量子点/二维MoS_(2)混合维异质结晶体管对视觉失忆行为治疗进行了模拟.其中,光电脉冲可以诱导足够多的电子来填充陷阱态并聚集于零维/二维混合维界面.同时,该异质结晶体管成功实现了生物中可重构的记忆/失忆行为和可调节的视觉记忆巩固功能.更为重要的是,通过实验还证明了光电协同脉冲修复可能对视觉失忆进行有效治疗.这项工作为医学记忆诊断系统、人机实时交互等领域的发展提供了一个新契机.

Amnesia is a common clinical disorder manifested by the loss of recent memory as well as global impairment in the ability to acquire new memories,which seriously affects normal life activities of humans.At present,although herbal intervention,protein synthesis inhibition,and hormone replacement can prevent or reverse amnesia,these treatments are relatively expensive and inefficient.Here,an advanced photoelectric-synergistically pulsatile therapy is used to emulate the treatment of visual amnesic behaviors using a zero-dimensional(0D)-carbon-quantum-dots/2D-MoS_(2)mixed-dimensional heterojunction transistor.The photoelectric pulse could induce enough electrons to fill the trap states and accumulate at the mixed-dimensional interface.The significant biological behaviors,such as reconfigurable memorizing/forgetting behaviors and adjustable visual memory consolidation,are successfully realized in the device.More importantly,the photoelectric-synergistically pulsatile therapy for the effective treatment of visual amnesia is experimentally demonstrated for the first time.These results may provide promising opportunities for the development of medical memory diagnosis systems and human-machine realtime interactions,etc.