0.3%玻璃酸钠联合卡波姆对干眼症患者的疗效分析

Analysis of efficacy of 0.3%sodium hyaluronate combined with carbomer on dry eye patients

目的探究0.3%玻璃酸钠联合卡波姆治疗干眼症患者的疗效。方法选取2019年1月至2022年1月舟山医院收治的80例干眼症患者,根据随机数字表法将纳入患者分为研究组和对照组,每组各40例。对照组患者给予0.3%玻璃酸钠治疗,研究组患者在此基础上加用卡波姆治疗,比较两组患者的眼表疾病指数(ocular surface disease index,OSDI)、视功能评分、Schirmer试验、炎症因子及不良反应。结果研究组患者的总有效率显著高于对照组(χ2=4.804,P=0.028)。治疗后,两组患者的OSDI、视功能评分、白细胞介素(interleukin,IL)-6、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、IL-1β均显著低于本组治疗前,泪液分泌量显著多于本组治疗前(P<0.05),且研究组患者的OSDI、视功能评分、IL-6、TNF-α、IL-1β均显著低于对照组,泪液分泌量显著多于对照组(P<0.05)。两组患者的不良反应比较差异无统计学意义(χ2=0.180,P=0.671)。结论0.3%玻璃酸钠联合卡波姆治疗干眼症疗效较好,可提高泪膜稳定性,增强视功能,降低泪液炎症因子表达,安全性较好。

Objective To investigate the efficacy of 0.3%sodium hyaluronate combined with carbomer in the treatment of patients with dry eye.Methods A total of 80 patients with dry eye treated in Zhoushan Hospital from January 2019 to January 2022 were selected and divided into study group and control group according to random number table method,with 40 cases in each group.Patients in control group were treated with 0.3%sodium hyaluronate,and patients in study group were treated with carbomer on this basis.Ocular surface disease index(OSDI),visual function score,Schirmer test,inflammatory factors,and adverse reactions were compared between two groups.Results The total effective rate in study group was significantly higher than that in control group(χ2=4.804,P=0.028).After treatment,OSDI,visual function score,interleukin(IL)-6,tumor necrosis factor-α(TNF-α),and IL-1βof the patients in both groups were significantly lower than before treatment,and volume of tear secretion was significantly higher than before treatment(P<0.05).OSDI,visual function score,IL-6,TNF-αand IL-1βof study group were significantly lower than those of control group,and volume of tear secretion was significantly higher than that of control group(P<0.05).There was no significant difference in adverse reactions between two groups(χ2=0.180,P=0.671).Conclusion 0.3%sodium hyaluronate combined with carbomer has good efficacy in the treatment of dry eye disease,can improve the stability of tear film,enhance visual function,reduce the expression of inflammatory factors in tear,and has good safety.