2019-2020年上海地区精子库有生育力男性精液质量及与季节变化关联性研究

A study of correlation between the semen quality of fertile men from sperm bank in Shanghai and the seasonal variationduring 2019 to 2020

目的:分析2019-2020年上海地区精子库有生育力男性精液质量及与季节变化的相关性。方法:回顾性收集2019年1月-2020年12月在复旦大学人类精子库捐献志愿者中770例有生育力男性初次精液样本检查数据,以同期上海地区气象学意义季节分组。采用多元线性回归分析季节变化与精液质量的相关性。结果:春、夏、秋、冬季节各组精液量分别为3.41±1.57ml、3.19±1.47ml、3.20±1.55ml、3.27±1.57ml,精子浓度分别为(69.88±32.29)×10^(6)/ml、(67.45±34.25)×10^(6)/ml、(62.36±28.04)×10^(6)/ml、(74.39±34.65)×10^(6)/ml,春季组和冬季组高于秋季组(P<0.05);前向运动率分别为(48.02±13.30)%、(47.83±11.53)%、(46.90±12.10)%、(47.31±11.52)%;精子总数分别为(237.41±144.09)×10^(6)/ml、(211.55±141.00)×10^(6)/ml、(200.47±130.77)×10^(6)/ml、(242.54±160.10)×10^(6)/ml,冬季组高于夏季组和秋季组(P<0.05)。季节因素影响25~29岁男性精子前向运动率(β=-0.148,P=0.049)。结论:本次调查季节因素是上海地区精子库捐精有生育力男性精液质量变化的影响因素之一,季节因素影响25~29岁年龄者精子前向运动率。

Objective:To analyze the correlation between the semen quality of fertile men from sperm bank in Shanghai and the seasonal variation during 2019 to 2020.Methods:The examination data of the initial semen sample donated by 770 fertile men as the volunteers from the human sperm bank of Fudan University during the period of January 2019 to December 2020 were collected retrospectively,and these men were grouped by the meteorologically significant seasons of the same period in the Shanghai area.Multiple linear regression was used to analysis the correlation between the sea-sonal changes and the semen quality.Results:The mean values of the semen volume of the men in the spring,sum-mer,autumn and winter season groups were 3.41±1.57 ml,3.19±1.47 ml,3.20±1.55 ml and 3.27±1.57 ml,re-spectively,and the mean values of sperm concentration of which were(69.88±32.29)×10^(6)/ml,(67.45±34.25)×10^(6)/ml,(62.36±28.04)×10^(6)/ml and(74.39±34.65)×10^(6)/ml respectively.Both the mean values of the semen vol-ume and the mean values of sperm concentration of the men in the spring and winter season groups were significantly higher than those of the men in the autumn season group(P<0.05).The mean values of the sperm forward motility of the men in the spring,summer,autumn and winter season groups were 48.02±13.30%,47.83±11.53%,46.90±12.10%and 47.31±11.52%,respectively,and the mean values of the total number of spermatozoa of which were(237.41±144.09)×10^(6)/ml,(211.55±41.00)×10^(6)/ml,(200.47±30.77)×10^(6)/ml and(242.54±160.10)×10^(6)/ml,respectively.Both the mean values of the sperm forward motility and the mean values of the total number of spermato-zoa of the men in the winter season group were significantly higher those of the men in the summer and autumn groups(P<0.05).The sperm forward motion rate of the men aged 25-29 years old were influenced by the seasonal factors(β=-0.148,P=0.049).Conclusion:The seasonal factor in this survey is one of the factors affecting the semen quality changes of the fertile men in Shanghai,in which,the seasonal factor influences the sperm forward motility of the men aged 25-29 years old.