超高龄经产妇不良妊娠结局危险因素分析

Analysis of the risk factors of the adverse pregnancy outcomes of super aged multiparous women

目的:研究粤东地区超高龄经产妇不良妊娠结局及其相关危险因素。方法:前瞻性纳入2020年6月-2022年4月本院诊断并治疗的超高龄经产妇120例,根据妊娠结局分为良好组及不良组,比较两组临床资料,使用多元回归分析不良妊娠结局危险因素。结果:不良组与良好组分娩孕周(39.0±1.0、37.7±1.8)周、新生儿体重(3160.1±380.5g、3040.9±591.1g)、甲状腺功能障碍(15.6%、3.6%)、妊娠期糖尿病(43.8%、25.0%)、糖尿病(23.4%、7.1%)、子宫肌瘤(43.8%、23.2%)有差异(均P<0.05)。相关性分析,分娩孕周、新生儿体重、甲状腺功能障碍、妊娠期糖尿病、糖尿病、子宫肌瘤与不良妊娠结局具有相关性,多因素logisti回归分析显示,分娩孕周较低、新生儿体重较高、合并甲状腺功能障碍、妊娠期糖尿病、糖尿病、子宫肌瘤均是造成超龄经产妇不良妊娠结局的危险因素。结论:临床应及时监控超龄经产妇上述危险因素以降低不良妊娠结局发生。

Objective:To study the adverse pregnancy outcomes and the related risk factors of super-aged multiparous women in the east of Guangdong province.Methods:This was a prospective study that included 120 superaged multiparous women diagnosed and treated in hospital from June 2020 to April 2022.These women were divided into group A(women with adverse pregnancy outcomes)and group B(women with normal pregnancy outcomes)according to their pregnancy outcomes.The clinical data of the women were compared between the two groups.Mul tivariate logistic regression was used to analyze the risk factors of the adverse pregnancy outcomes of the women.Results:The gestational weeks at delivery(39.0±1.0 weeks),the neonatal weight(3160.1±380.5g),the thyroid dysfunction rate(15.6%),the gestational diabetes mellitus rate(43.8%),the diabetes mellitus rate(23.4%)and the uterine fibroids rate(43.8%)of the women in group A were significantly different from those(37.7±1.8 weeks,3040.9±591.1g,3.6%,25.0%,7.1%and 23.2%)of the women in group B(all P<0.05).The correlation analysis showed that the gestational weeks at delivery,the neonatal weight,the thyroid dysfunction,the gestational diabetes mellitus,the diabetes mellitus and the uterine fibroids of the women were associated with their adverse pregnancy outcomes.Multivariate logistic regression analysis showed that the less gestational weeks at delivery,the higher neonatal weight,the thyroid dysfunction,the gestational diabetes mellitus,the diabetes mellitus and the uterine fibroids of the superaged multiparous women were all the risk factors of their adverse pregnancy outcomes.Conclusion:In clinical practice,the risk factors of the super aged multiparous women should be monitored in time to decrease the occurrence of their adverse pregnancy outcomes.