巨噬细胞向肌成纤维细胞转化对肾脏纤维化的影响

Macrophage to myofibroblast transition in renal fibrosis

肾脏纤维化是肾组织在持续慢性损伤过程中出现的以肾小球硬化、肾小管萎缩和肾间质纤维化为特点的病理性修复现象,是各种慢性肾脏病发展为终末期肾病的共同途径。巨噬细胞向肌成纤维细胞转化(MMT)是指骨髓源性巨噬细胞在肾损伤过程中分化为肌成纤维细胞并促进肾脏纤维化的一个过程。本文综述了MMT影响肾脏纤维化的一些证据和机制,以进一步了解MMT及其信号通路,寻找肾脏纤维化治疗的新靶点。

Renal fibrosis is a pathological repair phenomenon characterized by glomerular sclerosis,tubular atrophy and interstitial fibrosis that occurs in the process of chronic and sustained injury of renal tissue,and is a common pathway for various chronic renal diseases to develop into end-stage renal diseases.Macrophage-to-myofibroblast transition(MMT)is a process in which bone marrow-derived macrophages differentiate into myofibroblasts during kidney injury and promote renal fibrosis.Here,we summarize some evidence and mechanisms of MMT's influence on renal fibrosis,and further understanding of MMT and its potential signal pathways will be helpful in finding therapeutic targets for renal fibrosis.