基于《脾胃论》从肠道菌群探讨肥胖症的论治

Treatment of obesity from perspective of intestinal flora based on treatise on the spleen and stomach

肥胖是一种严重威胁人体健康的病理状态,表现为机体能量代谢失调,脂肪含量增加过多。目前市场上的减肥药虽然治疗效果明显,但安全性尚不能确定,因此出现了不少不良反应。研究显示,调节肠道菌群能有效改善肥胖,其机制主要涉及减少促进能量吸收和抑制激活炎症反应等多个方面,肠道菌群在肥胖发生和发展的过程中扮演着重要角色。中医认为,脾胃功能失调是肥胖的根本原因,从脾治肥胖在临床上是有效的。脾主运化水谷,肠道菌群影响消化吸收,两者生理功能相近,因此从肠道菌群入手阐述中医从脾论治肥胖的机制,为治疗肥胖提供了新的思路。

Obesity is a pathological state that seriously threatens human health, manifested by the imbalance of body energy metabolism and excessive increase of fat content. Although the treatment measures of weight loss drugs on the market are effective, many adverse reactions have occurred due to the uncertain safety. Studies have shown that regulating intestinal flora can effectively improve obesity, and its mechanism mainly involves promoting energy absorption, activating inflammatory reaction and other aspects. Intestinal flora plays an important role in the occurrence and development of obesity. Traditional Chinese medicine believes that the dysfunction of spleen and stomach is the root cause of obesity. It is clinically effective to treat obesity through the spleen. The spleen dominates the transportation of water and grain, and the intestinal flora affects digestion and absorption. The physiological functions of the two are similar. Therefore, the mechanism of treating obesity through spleen from the perspective of intestinal flora in traditional Chinese medicine is expounded, thus providing a new idea for the diagnosis and treatment of obesity.