ω-3 PUFA在心力衰竭中的研究进展

Advances in the study ofω-3 PUFA in heart failure

游离脂肪酸作为心脏重要的能量代谢底物,在各种心血管疾病中发挥着重要的作用,ω-3多不饱和脂肪酸(omega-3 polyunsaturated fatty acid,ω-3 PUFA)是游离脂肪酸的一个重要分支,越来越多的研究证实其与心血管疾病密切相关。心力衰竭为常见的心血管问题,严重影响着人们的生活质量,研究显示,ω-3 PUFA在心力衰竭的发生发展中起着重要作用。本文拟对ω-3 PUFA在心力衰竭中的代谢、作用机制及治疗中的意义进行综述。

Free fatty acids,as important energy metabolism substrates for the heart,play an important role in various cardiovascular diseases;ω-3 PUFA,as an important branch of free fatty acids,has been confirmed by more and more researches to be closely related to cardiovascular diseases.Heart failure,as a common cardiovascular problem,seriously affects people's quality of life.Studies have shown thatω-3 PUFA plays a significant role in the development of heart failure.In this paper,we try to review the metabolism,pathogenesis and therapeutic significance ofω-3 PUFA in heart failure.