口腔菌群与胃癌相关性的研究进展

Research Progress on Association Between Oral Bacteria and Gastric Cancer

胃癌是世界范围内严重威胁人类健康的一种癌症,其发生机制尚未完全明确,且大部分患者确诊时已是晚期。口腔是人体内仅次于肠道的第二大微生物库,口腔菌群与人体健康之间的联系也越来越受关注。近年来的一些研究发现口腔菌群与胃癌发生密切相关,口腔菌群特征具有作为胃癌无创诊断筛查生物标志物的潜质,而且口腔菌群失调、移位会促进胃癌的发生发展。本文对口腔菌群与胃癌的相关性进行综述,旨在为进一步阐明胃癌的发生发展机制、实现胃癌的早期无创筛查提供依据,并为后续开展相关研究提供参考。

Gastric cancer is one of the major types of cancer threatening human health worldwide.Its pathogenesis has not been fully elucidated,and patients are often diagnosed at an advanced stage.The oral cavity is the second largest microbial pool after the intestine in the human body,and thus the relationship between oral bacteria and human health is attracting increasing interest.Oral bacteria are closely related to gastric cancer and potentially serve as noninvasive diagnostic screening biomarkers for the disease.Imbalance in and displacement of these bacteria can promote the occurrence and development of gastric cancer.Hence,this article reviews the association between oral bacteria and gastric cancer,aiming to provide a basis for further elucidating the pathogenesis of gastric cancer and screening it early through noninvasive methods and serve as a reference for subsequent related research.