基于数据挖掘的藏医泻治方配伍规律及用药特点分析

Study on the medication rule of Tibetan medical catharsis therapy based on data mining

为藏医泻治方临床合理用药及新药研发提供理论依据,搜集《藏医经典文献集成》中关于历代藏医泻治方的古籍文献;共收集到92本有关藏医泻治方的古籍文献及356首藏医泻治方,应用SPPS Modeler 18软件分析法等方法,对其进行整理及分析,结果发现356首藏医泻治方中使用频次最高的前10的药物依次为白狼毒、长蝝诃子、巴豆、大果大戟、硇砂、大黄、漆树脂、荜拔、斑蝥、甘青大戟.其次,应用Apriori算法的关联规则分析法,将支持度设置为5%,置信度15%条件下发现94条藏医泻治方常用药对;其中白狼毒-长蝝诃子、白狼毒-巴豆、长蝝诃子-巴豆、白狼毒-大果大戟等是藏医泻治方2399条药对中最为常用的药物组合.356首藏医泻治方剂中使用频次最高的药物及组方关联最强的核心药对都以白狼毒、长蝝诃子、巴豆、大果大戟、硇砂等毒性较强的药物为主,而藏医临床上针对这些毒性药物具有非常严格的入药条件,必须经过专业的藏医炮制工艺技术,才能入药服用;同时,提高自身临床经验,确保泻治药物质量,搞清泻治药物炮制原理,掌握泻治疗法的具体操作方法是藏医泻治疗法临床合理应用的前提和所需条件.

To provide theoretical basis for clinical rational drug use and new drug research and development of Tibetan medicine purgative prescription,the ancient books and literatures about Tibetan medicine purgative prescription in the past dynasties in the Collection of Tibetan Medicine Classic Literature were collected;A total of 92 ancient books and literatures related to Tibetan medicine cathartic prescriptions and 356 Tibetan medicine cathartic prescriptions were collected.SPPS Modeler 18 software analysis method was used to sort out and analyze them.The results showed that the top 10 drugs used most frequently among the 356 first Tibetan medicine cathartic prescriptions were crotonic,big fruit spurge,sal ammoniac,rhubarb,urushi resin,piper,blister beetle,gansu qdu ji.Secondly,using the association rule analysis method of Apriori algorithm,94 commonly used pairs of Tibetan medicine prescription were found under the conditions of 5%support and 15%confidence.The white wolf poison-long myrobalan,white wolf,poison-crotonic,long myrobalancrotonic,white wolf poison-big fruit spurge,white wolf poison-paint resin,crotonic-big fruit spurge,long myrobalan-big fruit spurge,long myrobalan-rhubarb is Tibetan xie hong 2399 medicine to the most commonly used drug combinations.Among the 356 Tibetan medicine purgative prescriptions,the most frequently used drugs and the core drug pair with the strongest correlation are mainly the toxic drugs such as crotonic,big fruit spurge,sal ammoniac,rhubarb.However,Tibetan medicine has very strict drug application conditions for these toxic drugs in clinical practice,and they must go through professional Tibetan medicine processing technology before they can be taken into medicine.At the same time,improving their clinical experience,ensuring the quality of cathartic drugs,clarifying the processing principle of cathartic drugs,and mastering the specific operation methods of cathartic therapy are the prerequisite and necessary conditions for rational clinical application of Tibetan medicine cathartic therapy.