含半胱氨酸的天冬氨酸蛋白水解酶在急性肾损伤中的研究进展

Research advances of caspases in acute kidney injury

本篇综述中,我们总结了在脓毒症、缺血/再灌注、药物和横纹肌溶解等诱发的不同急性肾损伤中,含半胱氨酸的天冬氨酸蛋白水解酶介导细胞凋亡和焦亡的机制,以利于了解这些调控机制在急性肾损伤发生过程中的重要性,并促进发现治疗和预防急性肾损伤的精确靶点。

As a diverse group of conserved cysteine-containing aspartic protein hydrolases in cytoplasm,caspases are associated with apoptosis and inflammation.After an activation of macromolecular signaling complexes,they ultimately lead to programmed cell deaths of apoptosis and pyroptosis,depending on specific types of activated caspases.This review summarized the mechanisms of caspase-mediated apoptosis and pyroptosis in different types of acute kidney injuries(AKI)induced by sepsis,ischemia/reperfusion,drugs and rhabdomyolysis.The goal was to understand the importance of those regulators in AKI development and facilitate the discovery of precise targets for treating and preventing AKI.