蛋白质翻译后修饰在子痫前期发病机制中的研究进展

Research Advances on Protein Post-Translational Modification in the Pathogenesis of Preeclampsia

蛋白质翻译后修饰(post-translational modification)是指蛋白质在翻译后发生的一系列共价修饰,这些修饰能够调控蛋白质的结构和功能,因此对多种疾病的发生和发展产生影响。子痫前期(preeclampsia)是一种妊娠期特有的综合征,病因至今尚不明确。近年研究表明,蛋白质翻译后修饰可能在子痫前期的发病机制中发挥重要作用。综述常见的蛋白质翻译后修饰,如磷酸化、乙酰化、糖基化、泛素化和乳酸化等修饰在子痫前期发病机制中的研究进展,为探讨子痫前期的发病机制和改善诊治措施提供新的方向。

Protein post-translational modification refers to a series of covalent modifications that occur after protein translation.These modifications can regulate the structure and function of protein,thereby,affecting the development and progression of various diseases.Preeclampsia is a pregnancy-specific syndrome,but the cause of it is still not fully understood.Recent investigations suggest that post-translational modifications of proteins may play a crucial role in the pathogenesis of preeclampsia.In this article,we review the progress of common protein post-translational modifications,such as phosphorylation,acetylation,glycosylation,ubiquitination,and lactypation,in the pathogenesis of preeclampsia,which will provide new directions for exploring the pathogenesis of preeclampsia and for improving diagnostic and therapeutic measures.