荧光图像引导手术在妇科恶性肿瘤的研究进展

Progress of Fluorescence Image-Guided Surgery in Gynecological Malignant Tumors

荧光图像引导手术(fluorescence image-guided surgery,FIGS)是现代外科实践中的新兴技术,通过近红外荧光(near-infeared fluorecence,NIR)显像剂介导在手术中显影目的组织,作为实时、非侵入性和高分辨率的诊断方式,为手术医生提供屏幕图像,实现术中实时导航。FIGS在妇科恶性肿瘤可用于检测前哨淋巴结、淋巴造影、指示肿瘤边界、检测组织污染以及在手术中显影重要血管以评估血供等。由于NIR染料自身没有靶向性,与荧光染料结合的靶向分子探针正在被广泛研发并用于妇科恶性肿瘤的临床试验中,但假阳性率高仍是阻碍其临床应用的主要问题。随着新型荧光染料和成像系统的不断发展,FIGS可能会改变妇科恶性肿瘤的诊疗策略,为手术医生提供新的治疗选择。

Fluorescence image-guided surgery(FIGS)is a new technology in modern surgical practice,which uses near-infrared fluorescence(NIR)imaging agent to mediate the development of target tissue during surgery as a real-time,non-invasive and high-resolution diagnostic method to provide screen images for surgeons to achieve real-time intraoperative navigation.In gynecological malignant tumors,FIGS can be used to detect sentinel lymph nodes,perform lymphography,indicate tumor boundaries,detect tissue contamination and develop important blood vessels during surgery to evaluate blood supply.Due to the lack of targeting of NIR dye itself,targeted molecular probes combined with fluorescent dyes are being widely developed and used in clinical trials of gynecological malignant tumors.However,the high false positive rate is still the main problem hindering its clinical application.With the continuous development of new fluorescent dyes and imaging systems,FIGS may change the diagnosis and treatment strategy of gynecological malignant tumors and provide new treatment options for surgeons.