空间转录组技术在子宫内膜异位症免疫微环境研究中的应用前景

The Potential Application of Spatial Transcriptome Technology in the Research of Immune Microenvironment of Endometriosis

子宫内膜异位症(endometriosis,EMs)是育龄期妇女常见疾病,发病机制尚未明确。该病有着独特的类肿瘤表现,由细胞成分(如巨噬细胞、自然杀伤细胞和T淋巴细胞等)和非细胞成分共同构成的免疫微环境在异位病灶的发生发展中起重要作用。空间转录组技术作为一项近年来研究多种细胞间相互作用以及细胞空间连接的新技术,不仅可以描绘免疫微环境的整体图景,还可以用于探究免疫细胞在微环境中的动态发展和空间特异性。因此,空间转录组技术为EMs免疫微环境的深入探究提供了新技术和新思路。

Endometriosis is a common disease in women of childbearing age,and its pathogenesis has not yet been clarified.The disease has unique tumor-like characteristic,and the immune microenvironment,which consists of both cellular components(e.g.,macrophages,natural killer cells,and T-lymphocytes)and non-cellular components,plays an important role in the development of ectopic lesions.Spatial transcriptome technology,as a new technology to study multiple cellular interactions and cellular spatial connectivity in recent years,can not only provides an overall view of the immune microenvironment,but also be used to explore the dynamic development and spatial specificity of immune cells in the microenvironment.Therefore,spatial transcriptome technology provides a new technique and new insights for in-depth investigation of the immune microenvironment in endometriosis.