赭曲霉毒素A对动物的危害及脱毒研究进展

Research Progress on Harm of Ochratoxin A toAnimals and Its Detoxification

赭曲霉毒素A(OTA)是一种由曲霉或青霉产生的次级代谢产物,广泛污染谷物、水果和坚果等农产品和饲料,造成严重的经济损失。此外,越来越多的证据表明,OTA通过多种毒性作用(肾毒性、肝毒性、肠毒性、致癌性、致畸性和免疫毒性)对人类和动物的健康造成巨大威胁。因此,研究OTA的毒性机制,从多方面寻求解毒方法迫在眉睫。本文综述了OTA对动物的危害及其脱毒方法,重点讨论了各种OTA脱毒方法的优势和劣势,并对提高OTA脱毒效率的方法进行了深入探讨,以期降低饲料OTA的含量,有助于减少OTA对动物健康造成的危害。

Ochratoxin A(OTA)is a secondary metabolite produced by Aspergillus or penicillium,which widely contaminates agricultural products and feeds such as grains,fruits and nuts,causing serious economic losses.In addition,there is growing evidence that OTA poses a significant threat to human and animal health through multiple toxic effects(nephrotoxicity,hepatotoxicity,enterotoxicity,carcinogenicity,teratogenicity and immunotoxicity).Therefore,it is urgent to study the toxicity mechanism of OTA and seek detoxification methods from various aspects.In this paper,the harm of OTA to animals and its detoxification methods were reviewed,with emphasis on the advantages and disadvantages of various OTA detoxification methods,and the methods to improve the efficiency of OTA detoxification were discussed in depth,in order to reduce the content of OTA in feed and help reduce the harm caused by OTA to animal health.