紫杉醇联合顺铂治疗宫颈癌的临床效果

Clinical effect of paclitaxel combined with cisplatin on treatment of cervical cancer

目的分析宫颈癌患者使用紫杉醇联合顺铂(TP)进行化疗的临床效果。方法选择2021年5月—2022年5月遵义市第一人民医院收治的宫颈癌患者62例为研究对象,并按化疗方案分为A组(紫杉醇+卡铂)和B组(紫杉醇+顺铂),每组31例,从治疗有效率、不良反应发生率、治疗前后(WHOQOL-BREF评分、肿瘤标志物水平)、KPS评分(治疗前、治疗7 d、治疗1个月、治疗2个月、治疗3个月)等角度对比两组疗效。结果A、B组治疗有效率分别为74.19%、93.55%,比较差异有统计学意义(χ~2=4.292,P=0.038);A、B组不良反应总发生率分别为80.65%、54.84%,比较有统计学差异(χ~2=4.723,P=0.029);治疗前两组WHOQOL-BREF评分比较差异无统计学意义,治疗后两组评分较治疗前均升高(P<0.05),且B组高于A组(P<0.05);治疗前两组KPS评分比较差异无统计学意义,B组治疗7 d、1个月、2个月、3个月KPS评分均高于A组(P<0.05);治疗前两组肿瘤标志物水平比较差异无统计学意义,治疗后两组肿瘤标志物水平较治疗前均降低(P<0.05),且B组低于A组(P<0.05)。结论宫颈癌患者化疗中使用TP方案,能有效地改善肿瘤标志物水平,提升生存质量,疗效好,安全性高。

OBJECTIVE To observe the clinical effect of paclitaxel combined with cisplatin(TP)on treatment of the patients with cervical cancer.METHODS Totally 62 patients with cervical cancer who were treated in the First People's Hospital of Zunyi City from May 2021 to May 2022 were recruited as the study subjects and were divided into the group A(paclitaxel plus carboplatin)and the group B(paclitaxel plus cisplatin)according to chemothera-py regimens,with 31 cases in each group.The clinical effect was compared between the two groups by comparing the effective rate of treatment,incidence of adverse reactions,(WHOQOL-BREF score,levels of tumor markers)before and after treatment and KPS score(before treatment,7 days,1 month,2 months and 3 months after treat-ment).RESULTS The effective rate of treatment was 74.19%in the group A,93.55%in the group B,and there was significant difference(x2=4.292,P=0.038).The total incidence of adverse reactions was 80.65%in the group A,54.84%in the group,and there was significant difference(x2=4.723,P=0.029).There was no sig-nificant difference in the WHOQOL-BREF score between the two groups before the treatment,the score of the two groups was higher after the treatment than before the treatment(P<0.05),and the score of the group B was higher than that of the group A(P<0.05).There was no significant difference in the KPS score between the two groups before the treatment,and the KPS score of the group B was higher than that of the group A after the treat-ment for 7 days,1 month,2 months and 3 months(P<0.05).There were no significant differences in the levels of tumor markers between the two groups before the treatment,the levels of tumor markers of the two groups were lower after the treatment than before the treatment(P<0.05),and the levels of the tumor markers of the group B were lower than those of the group A(P<0.05).CONCLUSION The TP regimen can effectively improve the levels of tumor markers of the cervical cancer patients during chemotherapy and raise the quality of life,it is safe and highly effective.