卵巢癌合并感染性阴道炎阴道微生态及其危险因素

Vaginal microecological characteristics of ovarian cancer patients complicated with infectious vaginitis and risk factors

目的探讨卵巢癌(OC)患者合并感染性阴道炎(Ⅳ)阴道微生态变化及其危险因素。方法回顾性选取2020年6月-2023年2月赣州市人民医院收治的238例OC患者为研究对象,根据是否合并Ⅳ分为感染组72例和非感染组166例,统计OC合并Ⅳ的感染情况及阴道微生态特征,采用单因素及多因素Logistic分析OC合并Ⅳ危险因素。结果OC合并Ⅳ发生率为30.25%(72/238);72例OC合并Ⅳ患者中感染类型构成比由多到少依次为:阴道假丝酵母菌病32例(44.44%)、细菌性阴道炎26例(36.11%)、混合感染8例(11.11%)、滴虫性阴道炎5例(6.94%)和需氧菌性阴道炎1例(1.39%);多因素Logistic回归分析显示,年龄≥50岁、有阴道炎史、有化疗、性生活频率≥2次/周、文化程度初中以下及血清C-反应蛋白(CRP)≥10 mg/L、白蛋白(ALB)<30 g/L是OC合并Ⅳ的危险因素(P<0.05)。结论OC合并Ⅳ发生率高,感染类型以阴道假丝酵母菌病居多,细菌性阴道炎次之;年龄、阴道炎史、化疗、性生活频率、文化程度及血清C RP、ALB水平与Ⅳ发生相关。

OBJECTIVE To explore the vaginal microecological characteristics of the ovarian cancer(OC)patients complicated with infectious vaginitis(IV)and analyze the risk factors.METHODS Totally 238 OC patients who were treated in Ganzhou People's Hospital from Jun 2020 to Feb 2023 were recruited as the research subjects and were divided into the infection group with 72 cases and the non-infection group with 166 cases according to the sta-tus of complication with IV.The incidence of IV and vaginal microecological characteristics of the OC patients were statistically analyzed.Univariate analysis and multivariate logistic analysis were performed for the risk fac-tors for the IV in the OC patients.RESULTS The incidence of IV was 30.25%(72/238)among the OC patients.Among the 72 OC patients complicated with IV,there were 32(44.44%)cases of vaginal candidiasis,26(36.11%)cases of bacterial vaginitis,8(11.11%)cases of mixed infection,5(6.94%)cases of trichomoniasis vaginitis and 1(1.39%)case of aerobic bacteria vaginitis.Multivariate logistic regression analysis showed that the no less than 50 years of age,history of vaginitis,chemotherapy,frequency of sexual intercourse no less than twice per week,education level lower than junior high school,serum C-reactive protein(CRP)no less than 10 mg/L and albumin(ALB)level less than 30 g/L were the risk factors for IV in the OC patients(P<0.05).CONCLUSION The incidence of IV is high among the OC patients.Ther patients who are infected with vaginal Candida are dominant,followed by the patients with bacterial vaginitis.The occurrence of IV is associated with the age,history of vaginitis,chemotherapy,frequency of sexual intercourse,education level,serum CRP and ALB.