黄龙止咳颗粒联合布地奈德雾化治疗支气管哮喘患儿临床研究

Clinical Study on Huanglong Zhike Granules Combined with Aerosol Inhalation with Budesonide for Children with Bronchial Asthma

目的:观察黄龙止咳颗粒联合布地奈德雾化治疗支气管哮喘患儿的临床疗效。方法:选择82例支气管哮喘患儿,按随机数字表法分为对照组及观察组各41例。对照组予常规治疗,观察组在常规治疗基础上予黄龙止咳颗粒口服联合布地奈德雾化治疗。比较2组临床疗效、炎性因子及免疫功能指标。结果:治疗1周后,观察组总有效率92.68%,高于对照组78.05%(P<0.05)。治疗后,2组中医证候积分均降低(P<0.05),且观察组低于对照组(P<0.05)。治疗后,2组儿童哮喘控制测试(C-ACT)评分均升高(P<0.05),且观察组高于对照组(P<0.05)。治疗后,观察组第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)及FEV_(1)/FVC均升高(P<0.05),对照组FEV_(1)/FVC升高(P<0.05),且观察组FEV_(1)、FVC及FEV_(1)/FVC高于对照组(P<0.05)。治疗后,2组血清超敏C-反应蛋白(hs-CRP)及白细胞介素-6(IL-6)水平均降低(P<0.05),且观察组低于对照组(P<0.05)。治疗后,2组CD4^(+)、CD4^(+)/CD8^(+)均上升(P<0.05),CD8^(+)下降(P<0.05),且观察组CD4^(+)、CD4^(+)/CD8^(+)高于对照组(P<0.05),CD8^(+)低于对照组(P<0.05)。结论:黄龙止咳颗粒联合布地奈德雾化可有效减轻支气管哮喘患儿临床症状,改善肺功能,提高临床疗效,其机制可能与黄龙止咳颗粒能调节支气管哮喘患儿炎症反应及免疫应答,提高免疫功能有关。

Objective:To observe the clinical effect of the therapy of Huanglong Zhike Granules combined with aerosol inhalation with Budesonide on children with bronchial asthma.Methods:A total of 82 children with bronchial asthma were selected and divided into the control group and the observation group according to the random number table method.The control group was given routine treatment,and the observation group was additionally treated with Huanglong Zhike Granules combined with aerosol inhalation.The clinical effects,and indexes of inflammatory factors and immune function were compared between the two groups.Results:After one week of treatment,the total effective rate was 92.68%in the observation group,higher than that of 78.05%in the control group(P<0.05).After treatment,the traditional Chinese medicine(TCM)syndrome scores in both groups were decreased(P<0.05),and the TCM syndrome score in the observation group was lower than that in the control group(P<0.05).After treatment,the scores of Children Asthma Control Test(C-ACT)in both groups were increased(P<0.05),and the C-ACT score in the observation group was higher than that in the control group(P<0.05).After treatment,the forced expiratory volume in one second(FEV_(1)),forced vital capacity(FVC)and FEV_(1)/FVC in the observation group were increased(P<0.05),FEV_(1)/FVC in the control group was increased(P<0.05)and the FEV_(1),FVC and FEV_(1)/FVC in the observation group were higher than those in the control group(P<0.05).After treatment,the levels of serum hypersensitive C-reactive protein(hs-CRP)and interleukin-6(IL-6)in both groups were decreased(P<0.05),and the above levels in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of CD4^(+)and CD4^(+)/CD8^(+)in the two groups were increased(P<0.05),and the CD8^(+)levels were decreased(P<0.05);the levels of CD4^(+)and CD4^(+)/CD8^(+)in the observation group were higher than those in the control group(P<0.05),and the CD8^(+)level was lower than that in the control group(P<0.05).Conclusion:The therapy of Huanglong Zhike Granules combined with aerosol inhalation with Budesonide can effectively mitigate the clinical symptoms of children with bronchial asthma,and improve the lung function and clinical effect,whose mechanism may be related to that Huanglong Zhike Granules can adjust the inflammatory responses and immune responses of children with bronchial asthma and enhance the immune function.