摘要
目的:观察槐耳颗粒对中晚期原发性肝癌导管肝动脉化疗栓塞术(TACE)患者的临床疗效。方法:选取120例中晚期原发性肝癌患者为研究对象,按随机数字表法分为对照组和观察组各60例。2组均行TACE,对照组采用常规西药治疗,观察组在对照组基础上联合槐耳颗粒治疗,持续治疗30 d。比较2组临床疗效、不良反应持续时间,比较2组治疗前后卡氏功能状态(KPS)评分、血清甲胎蛋白(AFP)水平。结果:治疗后,观察组临床总有效率88.33%,高于对照组65.00%。观察组发热、腹痛、恶心呕吐、肝功能异常等不良反应持续时间均短于对照组(P<0.05)。术后2周、4周,2组KPS评分均逐渐升高(P<0.05),且同一时间点观察组高于对照组(P<0.05);2组中医证候积分均逐渐降低(P<0.05),且同一时间点观察组低于对照组(P<0.05)。术后2周、4周,2组血清AFP水平均逐渐降低(P<0.05),且同一时间点观察组低于对照组(P<0.05)。结论:槐耳颗粒联合西药可明显提高中晚期原发性肝癌TACE术患者的临床疗效,降低术后发热、腹痛、恶心呕吐、肝功能异常等不良反应的持续时间,改善患者生活质量,降低血清AFP水平。
Objective:To observe the clinical effect of Huaier Granules on patients with advanced primary liver cancer undergoing transcatheter arterial chemoembolization(TACE).Methods:A total of 120 cases of patients with advanced primary liver cancer were selected as the study objects and divided into the control group and the observation group according to the random number table method,with 60 cases in each group.Both groups were treated with TACE;the control group was treated with routine western medicine,and the observation group was additionally treated with Huaier Granules based on the treatment of the control group.Both groups were treated for 30 days.The clinical effects,duration of adverse reactions,Karnofsky Performance Status(KPS)scores and serum alpha-fetoprotein(AFP)levels were compared before and after treatment between the two groups.Results:After treatment,the total clinical effective rate in the observation group was 88.33%,higher than that of 65.00%in the control group.The duration of adverse reactions such as fever,abdominal pain,nausea,vomiting,and hepatic dysfunction in the observation group was shorter than that in the control group(P<0.05).In 2 and 4 weeks after surgery,KPS scores in the two groups were gradually increased(P<0.05),and the score in the observation group was higher than that in the control group at the same time point(P<0.05);traditional Chinese medicine syndrome scores in the two groups were gradually decreased(P<0.05),and the score in the observation group was lower than that in the control group at the same time point(P<0.05).In 2 and 4 weeks after surgery,the levels of serum AFP in the two groups were gradually decreased(P<0.05),and the level in the observation group was lower than that in the control group at the same time point(P<0.05).Conclusion:Huaier Granules combined with western medicine for patients with advanced primary liver cancer undergoing TACE can significantly improve the clinical effect,shorten the duration of postoperative adverse reactions such as fever,abdominal pain,nausea,vomiting,and hepatic dysfunction,improve the quality of life of patients,and reduce the levels of serum AFP.
作者
石星鹏
卢杰
SHI Xingpeng;LU Jie(Department of Hepatobiliary and Pancreatic Surgery,Taizhou Hospital,Taizhou Zhejiang 318050,China)
出处
《新中医》
CAS
2024年第1期191-195,共5页
New Chinese Medicine
基金
浙江省医药卫生科技计划项目(2022KY1377)。
关键词
原发性肝癌
经导管肝动脉化疗栓塞术
槐耳颗粒
中医证候积分
生活质量
甲胎蛋白
Primary liver cancer
Transcatheter arterial chemoembolization
Huaier Granules
Traditional Chinese medicine syndrome scores
Quality of life
Alpha-fetoprotein