米拉贝隆联合针灸治疗膀胱过度活动症患者(肾阳虚型)的临床分析

Clinical Analysis of Mirabegron Combined with Acupuncture and Moxibustion in Treating Patients with Bladder Hyperactivity(Kidney Yang Deficiency Type)

目的评价米拉贝隆联合针灸治疗膀胱过度活动症患者(肾阳虚型)的有效性和安全性。方法病例来自2021年10月至2023年4月由福建中医药大学附属人民医院(福建省人民医院)泌尿外科临床诊断轻、中度膀胱过度活动症(肾阳虚型)患者60例,按随机数字表法分为治疗组:口服米拉贝隆+针灸治疗(n=30),对照组:口服米拉贝隆(n=30)。采用生活质量评分表(QOL)、膀胱过度活动征评分(OABSS)分别于用药前1天、第4、6周分别记录并评分,采用尼莫地平法进行疗效的评价。结果治疗组与对照组在治疗4周后OABSS评分较同组治疗前下降(6.23±1.48)vs.(6.60±1.47),QOL评分较同组治疗前改善(4.07±0.85)vs.(4.10±0.75),但治疗组与对照组之间差异无统计学意义(t=-1.173,P>0.05),两组在治疗6周后,其症状进一步改善,OABSS评分为(2.80±1.38)vs.(4.50±1.78),QOL评分为(2.87±0.62)vs.(3.40±0.71)差别具有统计学意义(t=-4.462,P<0.05)。治疗组有效率为93.33%,对照组有效率为73.33%,两组治疗效果差异上具有统计学意义(χ^(2)=4.32,P<0.05)。治疗6周后,治疗组出现1例血压轻度升高,不良反应的发生率为3.33%(1/30);对照组出现1例短时间的心悸症状、1例血压轻度升高,不良反应发生率为6.67%(2/30),治疗组与对照组不良反应发生率差异无统计学意义(χ^(2)=0.351,P=0.554)。结论针灸联合米拉贝隆治疗膀胱过度活动症患者疗效显著。

Objective To evaluate the efficacy and safety of mirabegron combined with acupuncture and moxibustion in the treatment of patients with overactive bladder(kidney yang deficiency type).Methods From October 2021 to April 2023,60 patients with mild to moderate overactivity of the bladder(kidney yang deficiency type)were clinically diagnosed by the Department of Urology of the People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine(Fujian Provincial People's Hospital).According to the random number table,they were divided into the treatment group:oral mirabegron+acupuncture and moxibustion treatment(n=30),and the control group:oral mirabegron(n=30).The Quality of Life Scale(QOL)and Bladder Hyperactivity Scale(OABSS)were used to record and score the efficacy 1 day before medication,4 weeks,and 6 weeks after medication.The efficacy was evaluated using the nimodipine method.Results After 4 weeks of treatment,the OABSS score of the treatment group and the control group decreased(6.23±1.48)vs.(6.6±1.47),and the QOL score improved(4.07±0.85)vs.(4.1±0.75)compared with the same group before treatment.However,there was no significant difference between the treatment and the control group(t=-1.173,P>0.05).After 6 weeks of treatment,the symptoms of the two groups further improved,The OABSS score was(2.80±1.38)vs.(4.5±1.78),and the QOL score was(2.87±0.62)vs.(3.4±0.71).The difference was statistically significant(t=-4.462,P<0.05).The effective rate of treatment was 93.33%,and the effective rate of control group was 73.33%.The difference between the two groups was statistically significant(χ^(2)=4.32,P<0.05).After 6 weeks of treatment,1 case in treatment group had a slight increase in blood pressure,and the incidence of adverse reactions was 3.33%(1/30);One case of short-term palpitations and one case of slightly elevated blood pressure occurred in the control group.The incidence of adverse reactions was 6.67%(2/30).There was no statistical difference between the treatment group and control group(χ^(2)=0.351,P=0.554).Conclusions Acupuncture and moxibustion combined with mirabegron has a significant effect on patients with overactive bladder.