ApoE基因多态性与冠心病的研究进展

Research Progress of ApoE Gene Polymorphisms and Coronary Heart Disease

冠心病严重威胁人类健康,近年由于人们生活方式等因素的影响,冠心病的发病率逐渐升高。血脂水平是影响冠心病发生的危险因素之一,而载脂蛋白E(ApoE)作为影响血脂水平的重要因素,在脂质代谢中具有重要作用。ApoE基因多态性可通过不同作用机制直接或间接影响冠心病的发生,全面了解ApoE基因多态性与血脂水平及冠心病的相关性,可以为临床冠心病的预防及早期诊疗提供参考,并可优化患者的治疗方案,减少治疗过程中不良反应的发生。

Coronary heart disease poses a serious threat to human health,and affected by the change of people′s lifestyle and other factors,its incidence has shown a rapid increase in recent years.Blood lipid levels are one of the risk factors affecting the occurrence of coronary heart disease,and apolipoprotein E(ApoE),as an important factor affecting blood lipid levels,plays an important role in lipid metabolism.ApoE gene polymorphism can directly or indirectly affect coronary heart disease through different mechanisms of action.A comprehensive understanding of the correlation of ApoE gene polymorphism with blood lipid level and coronary heart disease can provide references for the clinical prevention and early diagnosis and treatment of coronary heart disease,optimize the treatment plan,and reduce the occurrence of adverse reactions during treatment.