乌蛇荣皮汤治疗维持性血液透析伴皮肤瘙痒患者的临床疗效及对患者免疫功能的影响

Clinical Efficacy and Impact on Immune Function of Wushe Rongpi Decoction in the Treatment of Maintenance Hemodialysis Patients with Skin Itching

【目的】探讨乌蛇荣皮汤用于维持性血液透析(MHD)伴皮肤瘙痒患者的临床疗效及对患者免疫功能的影响。【方法】本院收治的100例MHD伴皮肤瘙痒患者,随机分为观察组和对照组,每组50例。对照组采用临床常规治疗方案,观察组在此基础上加用乌蛇荣皮汤,比较两组治疗后临床疗效和不良反应发生情况及治疗前后中医症状评分、免疫功能指标及血清白介素-2(IL-2)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平。【结果】观察组患者总有效率为92.00%,高于对照组的78.00%(P<0.05);治疗后,观察组皮肤瘙痒、暗红色皮疹、红斑增多各项评分均低于治疗前及对照组治疗后(P<0.05);治疗后,观察组患者CD3^(+)、CD4^(+)水平明显高于治疗前及对照组,CD8^(+)水平明显低于治疗前及对照组(P<0.05);治疗后,观察组IL-2、IL-6、TNF-α水平低于治疗前及对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。【结论】采用乌蛇荣皮汤治疗MHD伴皮肤瘙痒患者的疗效显著,可改善患者免疫功能,降低血清IL-2、IL-6、TNF-α水平及中医症状评分,且不良反应发生率低。

【Objective】To explore the clinical efficacy of Wushe Rongpi decoction in maintenance hemodialysis(MHD)patients with skin itching and its impact on their immune function.【Methods】A total of 100 patients with MHD accompanied by skin itching admitted to our hospital were randomly divided into an observation group and a control group,with 50 cases in each group.The control group received routine clinical treatment,while the observation group received Wushe Rongpi decoction.The clinical efficacy and incidence of adverse reactions were compared between the two groups after treatment.The TCM symptom score,immune function indicators,and serum levels of interleukin-2(IL-2),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)were compared before and after treatment.【Results】The total effective rate of patients in the observation group was 92.00%,which was higher than 78.00%in the control group(P<0.05);The scores of skin itching,dark red rash,and increased erythema in the observation group after treatment were lower than those before treatment and in the control group after treatment(P<0.05);After treatment,the levels of CD3^(+)and CD4^(+)in the observation group were significantly higher than those before treatment and the control group,while the levels of CD8^(+)were significantly lower than those before treatment and the control group(P<0.05);The levels of IL-2,IL-6,and TFN-αin the observation group after treatment were lower than those before treatment and in the control group(P<0.05);There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).【Conclusion】The use of Wushe Rongpi decoction in the treatment of MHD patients with skin itching has a significant therapeutic effect,can improve the patient's immune function,reduce serum IL-2,IL-6,TFN-αlevels,and traditional Chinese medicine symptom scores,and has minimal adverse reactions.