子痫前期孕妇维生素D及血脂等实验室指标水平与妊娠结局分析

Analysis of laboratory indicators such as vitamin D and blood lipids and pregnancy outcomes in pregnant women with preeclampsia

目的探究孕妇血清维生素D、钙离子、血脂水平与子痫前期的关系,并分析子痫前期孕妇的妊娠结局。方法选取2021年1月1日至2023年1月1日于乌鲁木齐市妇幼保健院行孕期检查并分娩的166例子痫前期孕妇作为观察组,另选取同期200例健康孕妇作为对照组。检测两组血清维生素D、钙离子、磷离子、血脂、尿酸及肌酐等实验室指标水平,观察两组孕期并发症及妊娠结局。进一步采用多因素logistic回归模型分析子痫前期的影响因素。结果观察组血清维生素D、钙离子、高密度脂蛋白水平低于对照组,血清尿酸、肌酐水平高于对照组,差异均有统计学意义(P<0.05)。观察组胎儿生长发育迟缓、胎盘早剥、羊水过少、剖宫产、低出生体重儿、早产及产后出血发生率均明显高于对照组(P<0.05)。多因素logistic回归分析结果显示,血清维生素D(OR=15.141,95%CI:1.831~125.204,P=0.012)、钙离子(OR=4.625,95%CI:2.654~8.059,P<0.001)、高密度脂蛋白(OR=0.395,95%CI:0.235~0.666,P<0.001)、肌酐(OR=1.034,95%CI:1.005~1.063,P=0.020)及尿酸(OR=1.006,95%CI:1.003~1.010,P<0.001)水平均为孕妇发生子痫前期的独立影响因素。结论血清维生素D、钙离子、血脂、尿酸及肌酐水平可能与子痫前期的发生有关。

Objective To explore the relationship among serum vitamin D,calcium ion,blood lipid levels and preeclampsia in pregnant women,and analyze the pregnancy outcomes of pregnant women with preeclampsia.Methods A total of 166 pregnant women with preeclampsia who underwent pregnancy examination and delivered in Urumqi Municipal Maternal and Child Health Care Hospital from January 1,2021 to January 1,2023 were selected as the observation group,and 200 healthy pregnant women during the same period were selected as the control group.The levels of serum vitamin D,calcium ion,phosphorus ion,blood lipid indicators,uric acid,and creatinine were detected in the two groups,and the pregnancy complications and pregnancy outcomes were observed.The influencing factors of preeclampsia were analyzed by using multivariate logistic regression model.Results The levels of serum vitamin D,calcium ion,and high density lipoprotein in the observation group were lower than those in the control group,and the levels of serum uric acid and creatinine were higher than those in the control group,with statistical significance(P<0.05).The incidence of fetal growth retardation,placental abruption,oligohydramnios,cesarean section,low birth weight infants,premature delivery,and postpartum hemorrhage in the observation group were significantly higher than those in the control group(P<0.05).Multivariate logistic regression analysis showed that serum vitamin D(OR=15.141,95%CI:1.831-125.204,P=0.012),calcium ion(OR=4.625,95%CI:2.654-8.059,P<0.001),high-density lipoprotein(OR=0.395,95%CI:0.235-0.666,P<0.001),creatinine(OR=1.034,95%CI:1.005-1.063,P=0.020)and uric acid(OR=1.006,95%CI:1.003-1.010,P<0.001)were independent factors for the occurrence of preeclampsia in pregnant women.Conclusion The levels of serum vitamin D,calcium ions,blood lipids,uric acid and creatinine may be correlated with the occurrence of preeclampsia.