侵入式脑神经信号监测与调控技术研究进展

Recent progress in brain signal monitoring and neuromodulation technologies

脑科学研究是当今自然科学面临的一项重要挑战.大脑是人体的神经枢纽,控制着人体的各项生理活动.脑神经信号监测与调控技术能够建立大脑与外部设备之间的信息连接通路,从而实现对大脑中信息的读取以及对脑活动的控制,因此在疾病诊疗、军事、教育、娱乐等领域具有广阔的发展和应用前景.尽管目前脑神经信号监测与调控技术已经取得一定成果,但对于侵入式脑信号监测与调控技术的研究仍处于起步阶段.本文简要介绍脑神经信号监测与调控技术的基本原理,从信号获取、调控手段和电极制备等关键技术角度阐述侵入式脑信号监测与调控技术的国内外研究现状,讨论其面临的信号质量、调控准确性和生物安全等方面的挑战.最后,展望该技术在脑机接口等前沿领域中的应用前景.

Brain science research is an important challenge in today’s natural sciences.Over the past century,the main progress in brain science research was to understand the basic principles of neural information transmission and processing in neural networks.In recent years,with the development of new technologies in molecular biology and physiology,the molecular and cellular mechanisms of gene expression,neuronal differentiation,and neural connection formation during brain development have been revealed.Some neural circuits and electrical activity patterns related to brain functions have also been illuminated.Scientists are dedicated to conducting deeper research into brain science by establishing direct connections to the brain.The emergence of neural electrode technology allows to investigate and modulate large groups of neurons in different brain regions.Brain-computer interface(BCI)is a device that allows a direct communication path between the brain and external devices without relying on a conventional route(peripheral nerves,muscles,etc.).Brain neural signal monitoring and modulation technology is an important means of establishing information connection pathways between the brain and external devices,which plays an important role in signal acquisition and signal feedback in brain-computer interfaces.It is a cross-disciplinary technology,involving neuroscience,computer science,communication and information processing technology,artificial intelligence technology,etc.It shows broad development and application prospects,including disease diagnosis and treatment,science and education,military,education,entertainment,autonomous driving,industrial control,etc.To obtain higher spatiotemporal resolution and signal-to-noise ratio,it is necessary to promote invasive brain neural signal monitoring and modulation technology.Invasive electrodes usually face some issues such as biocompatibility,signal stability,and long-term durability,which inhibit their widespread applications in the real world.This paper briefly introduces the basic principles of brain neural signal monitoring and modulation technology,explains the research status of invasive brain neural signal monitoring and modulation technology from the perspective of key technologies such as signal acquisition,neuromodulation modalities,electrode preparation,and electrode structure design,and discusses challenges.Finally,we look forward to the application prospects of invasive brain neural signal monitoring and modulation technology in cutting-edge fields such as brain-computer interfaces.