T淋巴细胞亚群在儿童脓毒症免疫抑制中的作用

Research progress on T lymphocyte subsets in immunosuppression of sepsis in children

尽管目前对儿童脓毒症进行了大量研究,但其发病机制仍然存在争议和未解决的问题,免疫功能紊乱便是其中之一,而免疫抑制是免疫功能紊乱的核心部分,与脓毒症患者的病情进展、治疗选择、预后变化都有相关性。由于T淋巴细胞在免疫功能中扮演着至关重要的角色,因此在临床实践中,已将其视为判断免疫功能变化的重要指标。本文将对部分T淋巴细胞亚群引起免疫抑制的机制及其在脓毒症病情评估、预后、免疫干预的临床应用价值作一阐述。

Although a great deal of research has been done on sepsis in children,its pathogenesis remains controversial and unresolved,one of which is immune dysfunction.Immunosuppression is the core part of immune dysfunction,and it is related to the disease progression,treatment options,and prognosis changes in patients with sepsis.Since T lymphocytes play a crucial role in immune function,they have been regarded as an important indicator for judging changes in immune function in clinical practice.This review explained the mechanism of immunosuppression caused by some T lymphocyte subsets and its clinical application value in the evaluation,prognosis and immune intervention of sepsis.